Analysis Of Related Factors Of Intracranial Aneurysm Formation

Part One To analyze the risk factors of intracranial aneurysm formationObjective: To analyze the related risk factors of intracranial aneurysm formation.Methods: The selected time period was from January 2020 to August 2021.The location was the First Affiliated Hospital of Shantou University.The subjects were 187 hospitalized patients with intracranial aneurysms and 142 controls.By collecting the age,gender,personal history(including smoking history and drinking history),past history(including history of hypertension and coronary heart disease),and laboratory test results(including fasting blood glucose and blood lipid),the risk factors of intracranial aneurysm formation were analyzed by univariate analysis and multivariate logistic regression analysis.Results: In univariate analysis,the results showed that gender(or 1.61,95%confidence interval 1.03-2.50),smoking history(or 1.77,95% confidence interval 1.09-2.89),history of hypertension(0r 1.74,95% confidence interval 1.08-2.80)and fasting blood glucose were correlated with the formation of intracranial aneurysms(P < 0.05);There was no correlation between age,drinking history,coronary heart disease and blood lipid value(P > 0.05);In multivariate logistic regression analysis,the results showed that gender and smoking history were correlated with the formation of intracranial aneurysms,but other factors were not correlated.Conclusion: Female and smoking history are independent risk factors for the formation of intracranial aneurysms.Part Two Correlation between hemodynamic changes and intracranial aneurysm formationObjective: To investigate the correlation between hemodynamic changes and the formation of intracranial aneurysms.Methods: The cranial CTA imaging data of 478 patients hospitalized in the First Affiliated Hospital of Shantou University from January 2020 to August 2021 were collected to analyze the correlation between hemodynamic changes caused by Willis ring variation and intracranial aneurysms.Results: There are 478 subjects in this part of the study.There were 222 patients with intracranial aneurysms,which contained 239 aneurysms in total;There were 256 patients in the control group.Of the 478 patients,233 had vascular abnormalities.In the case group,there were 239 intracranial aneurysms,of which 78 were caused by abnormal blood vessels,accounting for 32.64%;In the control group,there were 90 congenital vascular variants in 256 patients.There were 63 anterior communicating aneurysms,of which 32 cases were complicated with A1 dominant sign,accounting for 50.79%,or value was 5.18,95% confidence interval: 2.96-9.04,P < 0.05;There were 32 posterior communicating aneurysms,of which 11 cases were absent of PCo A and pcap1,accounting for 34.38%,or value was 2.81,95% confidence interval: 1.30-6.09,P < 0.05.Conclusion: Hemodynamic changes are an important factor in the formation of intracranial aneurysms.Al dominance sign is important for the formation of anterior communicating aneurysms,and Willis posterior ring variation is important for the formation of posterior communicating aneurysms.