Expression Of LIGHT In Multiple Myeloma And Its Correlation With IL-6

Objective: By detecting the concentrations of LIGHT and IL-6 in the plasma of patients with multiple myeloma(MM),To explore the relationship between LIGHT and IL-6 with clinical features and disease stages of MM patients,and to analyze the role of LIGHT and IL-6 in the pathogenesis of MM.The expression level of IL-6 in the renal impairment group was higher than that in the no renal impairment group,and the IL-6 expression level in the anemia group was higher than that in the non-anemia group(P<0.05).There was no significant difference between the groups without anemia(P>0.05).Methods:A total of 28 patients with MM and 28 healthy controls in the Qinghai Univer_sity affiliated Hospital from September 2019 to December 2021 were collected.The plasma concentrations of LIGHT and IL-6 in 28 patients with MM and 28 healthy controls were measured by ELISA.The clinical data of the subjects in each group were collected,the differences of LIGHT and IL-6 in the two groups were compared,and the correlation between LIGHT and IL-6 in MM patients was analyzed.Results: 1.Compared with the control group,the average levels of LIGHT and IL-6 in MM patients were significantly increased(P<0.05).In MM patients,the expression levels of LIGHT,IL-6 and CRP in the bone disease group were higher than those in the no bone disease group(P<0.05),while the ALB level was lower than that in the no bone disease group(P<0.05).The expression level of IL-6 in the renal impairment group was higher than that in the no renal impairment group,and the IL-6 expression level in the anemia group was higher than that in the non-anemia group(P<0.05).There was no significant difference between the groups without anemia(P>0.05).2.In DS stage of MM group,the concentration of LIGHT in stage III was higher than that in stage I + stage II(P<0.05);while in ISS stage,there was no statistical difference between LIGHT in stage III and stage I + stage II significance(P>0.05).3.In DS staging of MM group,there was no significant difference between IL-6 in stage III and stage I + stage II(P>0.05);while in ISS staging,the concentration of IL-6 in stage III was higher than that in stage III.Stage I + stage II(P<0.05).4.In MM group,IL-6 was negatively correlated with HB(r_s =-0.404,P<0.05);IL-6 was positively correlated withβ2-MG and ESR(r_s were 0.575,0.499,both P<0.05));while there was no correlation between LIGHT and IL-6(r_s=0.063,P>0.05).5.The optimal cut-off values of LIGHT and IL-6 for the diagnosis of myeloma bone disease(MBD)were 1495.14pg/ml and17.92pg/ml,respectively;the sensitivity was 75% and 70%,and the specificity was87.5% and 87.5%,respectively.Conclusion: 1.The expression levels of LIGHT and IL-6 in the plasma of MM patients were higher than those of the control group,indicating that LIGHT and IL-6 play an important role in the occurrence and development of MM.2.The higher the ISS stage,the higher the level of IL-6,indicating that the level of IL-6 can reflect the tumor burden and disease progression of MM patients to a certain extent.3.LIGHT and IL-6 have certain clinical value in the diagnosis of myeloma bone disease.