The Significances Of Serum Free Light Chains (sFLCs) Measurement In Multiple Myeloma And Myeloma Bone Disease

Objective：1.To evaluate the clinical significance of sFLC in multiple myeloma (MM);2.Todissuss the relationship between sFLC and myeloma bone disease。Methods：To dectect sFLC content in27newly diagnosed MM patients and30healthypeople using immuno-nephelometric assay； we evaluate their significances in MMpatients‘diagnosis and prognosis；and analyzed their correlations with some other clinicalparameters；we also trace19MM patients who receive chemotherapy and measured theirsFLC levels to investigate the significances of sFLC in patients prognosis；in addition,wetest26newly diagnosed MM patients with MBD and dissuss the relationship between sFLCand myeloma bone disease.Results：1.In27MM newly diagnosed patients,we notice that27patients (100%) weredetected with abnormal sFLCs and it was more sensitive than immunofixationelectrophoresis and serum protein electrophoresis.2..The sFLC degree of decline are related to treatment efficy.3. The sFLC-κlevels are related to MBDConclisions：The measurement of sFLC by immuno-nephelometric assay was sensivitive inMM diagnosis and can reflect the prognosis and degree of MBD.2.The measurement of sFLC is a simple and convenient test and worthy of promotion.