Effect Of Sublingual Immunotherapy On Asthmatic Children With Dust Mite

Object: Bronchial asthma is a common chronic respiratory disease in children.Allergic asthma is the main type of asthma in children,and dust mite is the main allergen,which may provide an opportunity for targeted treatment.AIT mainly includes sublingual immunotherapy(SLIT)and subcutaneous immunotherapy(SCIT).At present,the application of SCIT in asthma treatment has achieved initial results,but the effectiveness of SLIT in asthma treatment still lacks the support of clinical evidence.By evaluating the clinical efficacy of SLIT in children with dust mite allergic asthma,this thesis provides clinical evidence for promoting the effectiveness of SLIT as a standardized treatment of asthma,so that children’s asthma can be better controlled and treated.Methods: A total of 70 children with mild to moderate asthma who were diagnosed in Shaoxing People’s Hospital from October 2019 to March 2021 were divided into SLIT group(n=36)and control group(n=34)according to whether or not to use SLIT.Both groups completed a one-year course of treatment.In the baseline period,the indicators of the two groups were not statistically significant and comparable.Observation indexes include: times of acute asthma attacks per year,children’s asthma quality of life questionnaire,children’s asthma symptom test,rhinitis symptoms,pulmonary function(FEV1%),medication score,etc.Results: 1.Comparison between groups: After 6 months and 12 months of treatment,the total score of children’s asthma quality of life,the scores of symptoms,activities and emotions,and the control score of asthma symptoms in SLIT group are better than those in the corresponding control group,and the difference is statistically significant(P<0.05).After 12 months of treatment,the number of acute asthma attacks per year,medication score and FEV1% in the treatment group were all better than those in the corresponding control group,and the difference was statistically significant(P<0.05).2.Intra-group comparison: After 6 months and 12 months of treatment,the total score of asthma quality of life in SLIT group,the three dimensions of symptoms,activities and emotions,and the control score of asthma symptoms were statistically significant compared with those before treatment(P<0.05),but there was no significant difference in the above-mentioned indexes in control group.After 12 months of treatment,the times of acute asthma attacks per year,medication score group and FEV1% in the SLIT group were statistically significant compared with those before treatment(P<0.05),but there was no significant difference in the control group.3.After one year of treatment,the rhinitis symptom score of the treatment group was better than that of the control group,and there was a statistical difference between the two groups(P<0.05).4.During the whole follow-up period,no serious adverse reactions were reported in both groups.Conclusion: SLIT,as an additional treatment for asthma routine treatment,can reduce the number of acute asthma attacks,improve asthmatic children’s life quality,better control asthma symptom,and reduce the use of asthma drugs.SLIT is an effective and safe treatment method.