Clinical Observation Of Clearing Stomach Heat And Removing Spleen Dampness In Treatment Of Abnormal Lipid Metabolism Of Obese PCOS In Childbearing Age

Objective:To observe and evaluate the efficacy and safety of clearing stomach heat and removing spleen dampness in the treatment of abnormal lipid metabolism of obese polycystic ovary syndrome in childbearing age,in order to provide a new direction for the treatment of this disease.Methods:Forty-one patients who visited the Department of Gynecology of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from October 2020 to January 2022 were included in this study.The condition of these people was consistent with obese PCOS with dyslipidemia in childbearing age,and the TCM syndrome type was gastric heat and dampness resistance syndrome type.According to their own before and after comparison,using the method of clearing stomach heat and spleen dampness,the patient was given oral treatment for 3 months with the prescription created by the tutor to regulate menstruation and improve blood lipids.The changes of menstrual cycle,TCM symptoms,obesity(body weight,body mass index,waist-to-hip ratio),serum total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and sex hormone values were observed before and after taking Chinese herbal medicine.Results:1.A total of 41 patients were included in this study,including 2 cases of detachment and the remaining 39 cases.After treatment,1 case was cured,3cases were markedly effective,28 cases were effective and 7 cases were ineffective,and the total effective rate was 82.05%.There was no adverse reaction in patients during the process.2.The menstrual cycle of the patients was improved after treatment(P<0.05).The bidirectional rate of basal body temperature was 35.8% before treatment,and increased to 69.2% after treatment.During the follow-up period,three of the 17 women who wanted to get pregnant were successful,including one who was infertile.3.After treatment,the total score of TCM syndrome decreased from15.33±2.84 to 7.82±2.76,P<0.05.Moreover,each single score of TCM symptoms,such as obesity,limb weight and laziness,dry mouth and bad breath,abdominal distension and so on,was improved in different degrees.4.Symptom scores of acne and acanthosis nigricans decreased after medication,and the differences were significant(P<0.05).Body weight,BMI and WHR related to obesity were decreased,and the differences were significant(P<0.05).The treatment effect of ovarian volume and hirsutism was not significant(P>0.05).5.After treatment,the levels of LH and T in blood decreased,and the differences were statistically significant.FSH had no significant change and the difference was not statistically significant.6.It has certain positive effect in improving dyslipidemia.After treatment,TC,TG and LDL-C decreased,HDL-C increased,the differences were statistically significant(P<0.05).Conclusion:The method of clearing stomach heat and removing spleen dampness has definite efficacy and good safety.It can effectively improve the clinical manifestations and TCM symptoms of obese PCOS patients,and regulate the menstrual cycle,sex hormone levels and lipid metabolism.It also has certain positive effect on improving the fertility of patients.It provides an idea for clinical treatment of obese polycystic ovary syndrome(syndrome of gastric heat and dampness resistance)combined with dyslipidemia in childbearing age.