| Objective:To observe the clinical efficacy of Jiawei Jiaotai Decoction in treating type 2 diabetes mellitus with insomnia due to heart-kidney disharmony,and its influence on melatonin,5-HT and blood sugar indexes,and explore its mechanism,so as to provide theoretical basis for its treatment of type 2diabetes mellitus with insomnia due to heart-kidney disharmony.Methods:The source of the cases was 60 patients who met the inclusion criteria from December 2020 to December 2021 in the endocrine clinic of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine.Patients were treated with Jiawei Jiaotai Decoction on the basis of keeping the original hypoglycemic scheme.Four weeks is a course of treatment,and two courses are observed.The PSQI scores and TCM syndrome scores of patients were recorded before treatment,4 weeks after treatment and8 weeks after treatment.The changes of fasting blood glucose,2-hour blood glucose,glycosylated hemoglobin,melatonin,5-HT,PSQI and TCM syndrome integral indexes were compared before and after treatment.SPSS26.0statistical software was used for data analysis.Results:1.Comparison of TCM syndrome scores: After 4 weeks and 8 weeks of treatment,the total scores of TCM syndromes of patients decreased(P < 0.05),and after 8 weeks of treatment,the scores of individual TCM symptoms of patients decreased(P < 0.05).After 2 months of follow-up,there was no significant difference between the scores of TCM syndromes of patients and those after 8 weeks of treatment(P>0.05).2.Comparison of scores of PSQI and various factors: After 4 and 8 weeks of treatment,the total scores of PSQI decreased(p < 0.05),after 8 weeks of treatment,after 2 months of follow-up,the total scores of PSQI decreased compared with those before treatment(p < 0.05),and after 2 months of follow-up,there was no significant difference between the total scores of PSQI and those after 8 weeks of treatment(P>0.05).3.Comparison of FPG,2h PG and Hb A1c: FPG,2h PG and Hb A1 c decreased after4 weeks and 8 weeks of treatment(P<0.05);4.Comparison of 5-HT and melatonin before and after treatment: After 4weeks and 8 weeks of treatment,the melatonin of patients increased significantly(P<0.05),and the 5-HT of patients after treatment increased significantly(P<0.05);5.Comparison of TCM syndrome curative effect and insomnia curative effect: The total effective rate of TCM syndrome curative effect after 8 weeks of treatment is 95%.The total effective rate of insomnia was 91.67%6.Safety: During the treatment period,there were no obvious abnormal changes in blood routine,stool routine,urine routine,liver and kidney function,electrocardiogram and other biochemical indexes.Conclusion:1.Jiawei Jiaotai decoction can improve patients’ clinical symptoms and reduce TCM syndrome score and PSQI score.2.Jiawei Jiaotai decoction may have the effect of synergistic regulation of FPG,2h PG and Hb A1 c levels.3.Jiawei Jiaotai decoction can improve the levels of melatonin and 5-HT,and plays a certain role in improving the sleep quality of patients. |
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