Cervical Instability And Carotid Atherosclerotic Plaque Correlation Studies

Objective:To study whether cervical instability is a risk factor for the formation of carotid atherosclerotic plaque,and to explore the role of cervical instability and other risk factors in the pathogenesis of carotid atherosclerotic plaque,so as to provide theoretical basis for the prevention and treatment of carotid atherosclerotic plaque.Methods:A retrospective study was conducted to select 215 patients(40 years old<age<65 years old)who were hospitalized in the Affiliated Hospital of Youjiang Medical College for Nationalities from October 2020 to October 2021.Gender.age,smoking history.drinking history,body mass index,coronary heart disease history,cerebral infarction history,hyperuricemia,hyperlipidemia,hypertension,diabetes,hyperhomocysteinemia,cervical instability and cervical segmental instability were collected and recorded 105 patients with carotid atherosclerotic plaque diagnosed by color Doppler ultrasound were selected as the case group,and 110 patients without carotid atherosclerotic plaque were selected as the control group.The correlation between cervical instability and carotid atherosclerotic plaque was explored by statistical methods.Results:(1)There were 49 males and 56 females in the case group,with an average age of 57.02 ± 6.512 years There were 47 males and 63 females in the control group,with an average age of 56.48 ±8.373 years.Ther e was no significant difference between the two groups in gender(P=0.561)and age(P=0.601)(P>0.05).(2)Comparison of clinical data between case group and control group:hypertension,diabetes,history of cerebral infarction,hyperlipidemia,hyperhomocysteinemia,cervical instability P values were less than 0.05,the difference was statistically significant.Smoking history(P=0.125),drinking history(P=0.257),coronary heart disease history(P=0.129),hyperuicemia(P=0.604).BMI(P=0.258),the above P values were>0.05,the difference was not statistically significant.(3)There was no significant difference between the case group and the control group in the instability of C4/5 segment(P<0.05).(4)Six factors with statistically significant differences after single factor analysis were selected as independent variables,namely hypertension,diabetes,history of cerebral infarction,hyperlipidemia,HHCY,and cervical instability.The dependent variable was whether there was carotid atherosclerotic plaque.The regression method was used to gradually eliminate the non-significant indigenous variables,and the binary Logistic regression model 1 was established.The results showed that the P values of hypertension(OR=6.304,P<0.01),diabetes(OR=2.498,P=0.042).hyperlipidemia(OR=2.484,P=0.015)and cervical instability(OR=1.99,P=0.046)were<0.05,and the difference was statistically significant.(5)In order to futher analyze the influence of cervical instability of different segments on the formation of carotid atherosclerotic plaque,the statistical significance of C4/5 and C5/6 segment instability was introduced into the independent variables of the binary Logistic regression equation to replace the cervical instability variables,and then the binary Logistic regression analysis was used.The backward method was used to gradually eliminate the non-significant indigenous variables,and the binary Logistic regression model 2 was establishe d.The results showed that the P values of hypertension(OR=6.463,P<0.01),diabetes(OR=2.587,P=0.035).hyperlipidemia(OR=2.477,P=0.015)and C4/5 segmental instability(OR=2.407,P=0.036)were<0.05,and the difference was statistically significant.Conclusion:(1)This study found that cervical instability may be an independent risk factor for carotid atherosclerotic plaque formation,and in the common cervical instability segments,C4/5 segment instability may be more likely to induce carotid atherosclerotic plaque formation than other segments.(2)This study found that hypertension.hyperlipidemia and diabetes may be independent risk factors for carotid atherosclerotic plaque formation.