Diagnostic Significance Of Inflammatory Indicators For Bacterial And Viral Skin Diseases

Objective:In this study,white blood cell(WBC),serum procalcitonin(PCT),serum amyloid protein(SAA)and C-reactive protein(CRP)levels were detected in bacterial skin diseases,viral skin diseases and healthy people.These levels were detected to observe the difference in the range of changes of inflammatory indicators in blood when the body was infected with different infections,and the combined analysis was conducted,so as to explore the diagnostic value of WBC,PCT,SAA and CRP in bacterial skin diseases and viral skin diseases.In order to provide reference significance for the diagnosis of clinical infectious diseases.Methods:From August 2019 to June 2021,64 cases of inpatients with bacterial infectious diseases in our hospital were chose as bacterial infection group;189 cases of viral skin diseases in this hospital during the same period were selected as virus infection group;35cases of healthy people were defined as the control group.General data of the patients including age and gender were collected,and elbow venous blood was extracted from all subjects 12 hours after fasting.Discuss the diagnostic value of single and combined detection indicators in bacterial skin diseases and viral skin diseases by detecting the whole blood WBC and serum PCT,SAA,CRP levels of each group and plotting receiver operator characteristic(ROC)curves.Results:1.The age and gender of control group,bacterial infection group and virus infection group were compared,and no significant statistical difference was found (P>0.05).The levels of WBC,PCT and SAA in bacterial infection group were all higher than virus infection group and control group,PCT and SAA in virus infection group were higher than control group,while WBC was lower than control group.The proportion of CRP lower than normal value and CRP higher than normal value in the three groups showed statistically significant difference(P< 0.001),the proportion of CRP higher than normal value in bacterial infection group was higher than that in virus infection group,the difference was statistically significant(P < 0.001).2.When WBC,PCT,SAA and CRP were used to diagnose bacterial skin diseases, the AUC(area under ROC curve)of WBC was 0.817;The AUC of PCT in the diagnosis of bacterial skin diseases was 0.879;The AUC of SAA in the diagnosis of bacterial skin diseases was 0.838;The sensitivity and specificity of CRP in the diagnosis of bacterial skin diseases were 100% and 41.7% severally.The AUC of WBC combined with PCT in the diagnosis of bacterial skin diseases was 0.920;While the combined value of the WBC,PCT and SAA in the diagnosis of bacterial skin diseases was 0.936.3.When WBC,PCT,SAA and CRP were used to diagnose viral skin diseases,the AUC of WBC was 0.675;The AUC of PCT in the diagnosis of viral skin diseases was 0.725;The AUC of SAA in the diagnosis of viral skin diseases was 0.684;The sensitivity and specificity of CRP in diagnosis of viral skin diseases were 79.9% and 100% severally.WBC combined with PCT diagnosed viral skin diseases with an AUC of 0.719;The combined value of the WBC,PCT and SAA in the diagnosis of viral skin diseases was 0.695.Conclusion:WBC of bacterial infection group was higher than normal value,WBC of virus infection group was lower than normal value.For bacterial and viral infection group,PCT and SAA levels were higher than normal,but the bacterial infection group increased significantly,the difference was statistically significant.Therefore,WBC could be used to distinguish bacterial skin diseases from viral skin diseases.SAA could not distinguish the infection type of skin disease;CRP had the highest sensitivity in diagnosis of bacterial skin infections.When CRP was higher than normal value,it was more valuable to diagnose bacterial skin diseases.The diagnostic value of combination of the three indicators was higher than that of the WBC,PCT and SAA separately.WBC combined with PCT was of certain valuable in the diagnosis of viral skin diseases.