| Objective:To investigate the changes of serum asprosin and irisin levels in patients with newly diagnosed type 2 diabetes mellitus(T2DM)and the correlation between the two factors,and provide new ideas for the early prevention and treatment of T2DM.Methods:1.Research samples: 44 newly diagnosed type 2 diabetes patients(T2DM group)and44 healthy subjects(NGT group)who were enrolled in the Second Hospital of Shanxi Medical University from November 2020 to April 2021.2.Routine data collection: Age and sex of the subject were recorded and height,weight,systolic blood pressure(SBP),diastolic blood pressure(DBP)were measured.3.Clinical data collection: Fasting blood glucose(FPG),2 hour postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),triglyceride(TG),total cholesterol(TC),asprosin,irisin were measured and recorded in the subjects.4.Body mass index(BMI),insulin resistance index(HOMA-IR)and islet β cell function index(HOMA-β)were calculated.Results:1.Comparison of basic clinical data between the two groups: There were no significant differences in gender,BMI,TC and LDL-C between the two groups(P>0.05);Age,SBP,DBP,TG,FPG,2hPG,FINS,HbA1 c and HOMA-IR levels in T2DM group were significantly higher than those in NGT group(P<0.05);HDL-C and HOMA-β levels were significantly lower than those in NGT group(P<0.05).2.Comparison of serum asprosin and irisin levels between the two groups: Serum asprosin level in T2DM group was significantly higher than that in NGT group(1.73 vs1.11 ng/ m L,P<0.001);serum irisin level in T2DM group was significantly lower than that in NGT group(2.55 vs 4.26 ug/ m L,P<0.001).3.Spearman correlation analysis of asprosin,irisin and related indicators: Asprosin was positively correlated with LDL-C,FPG,2hPG,FINS,HbA1 c,HOMA-IR(r=0.244,P<0.05),(r=0.392,P<0.001),(r=0.373,P<0.001),(r=0.349,P<0.05),(r=0.301,P<0.05),(r=0.290,P<0.05),were negatively correlated with HOMA-β(r=-0.235,P<0.05);irisin was negatively correlated with TG,LDL-C,FPG,2hPG,FINS,HbA1 c,HOMA-IR(r=-0.239,P<0.05),(r=-0.224,P<0.05),(r=-0.429,P<0.001),(r=-0.571,P<0.001),(r=-0.404,P<0.001),(r=-0.463,P<0.001)(r=-0.431,P<0.001),were positively correlated with HDL-C,HOMA-β(r=0.265,P<0.05),(r=0.307,P<0.05);asprosin was negatively correlated with irisin(r=-0.510,P<0.001).4.Multiple stepwise regression analysis: FINS and HOMA-β were independent influencing factors of serum asprosin level(P<0.05),and the regression equation was Y=1.438+0.082X1-0.011X2(X1=FINS,X2=HOMA-β).2hPG was an independent influencing factor of serum irisin level(P<0.05),and the regression equation was Y=5.657-0.248X1(X1=2hPG).5.Logistic regression analysis: Serum asprosin was a risk factor for T2DM(OR:9.931,95% CI:2.186,45.122,P=0.003)and serum irisin was a protective factor for T2DM(OR:0.441,95%CI :0.234,0.832,P=0.011).Conclusion:1.Compared with the NGT group,the serum asprosin level was significantly higher and the serum irisin level was significantly lower in the T2DM group,suggesting that asprosin and irisin may be related to T2DM.2.Asprosin was positively correlated with LDL-C,FPG,2hPG,FINS,HbA1 c,HOMA-IR and negatively correlated with HOMA-β.Irisin was positively correlated with HDL-C,HOMA-β and negatively correlated with TG,LDL-C,FPG,2hPG,FINS,HbA1 c,HOMA-IR.Asprosin was negatively correlated with irisin,suggesting that asprosin and irisin may be related to glucose metabolism,lipid metabolism and insulin resistance,and the two factors may regulate each other in human body.3.Serum asprosin was a risk factor for T2DM and serum irisin was a protective factor for T2DM.Multiple stepwise regression analysis showed that FINS and HOMA-β were independent influencing factors of asprosin and 2hPG was independent influencing factor of irisin,suggesting that asprosin and irisin may be closely related to glucose metabolism and islet β cell function,and participate in the occurrence and development of T2DM. |
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