Traditional Chinese Medical Syndrome Characteristics Of Cervical Intraepithelial Neoplasia(CIN1)

ObjectiveThe Application of Cluster analysis was to investigate the TCM syndrome types of patients with CIN1 clinically diagnosed,to evaluate the correlation of every syndrome type with age,sexual life,gestation-parturition,p16 and HPV situation,and to preliminarily explore the distribution of CIN1 female syndrome types in the People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine and its relationship with some relevant factors,which is of certain significance for the prevention of the disease and the combination of disease differentiation and syndrome differentiation.Methods135 patients diagnosed with CIN1 in the People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine were collected and their basic situation,HPV situation&TCM symptoms,signs and tongue vein condition were recorded in this study where those items with the frequency of TCM symptoms,signs and tongue vein > 5% were entered into SPSS22.0 in the form of yes(1)or no(0).The distribution of CIN1 syndrome types was counted by cluster analysis,and the correlation of every syndrome type with age,sexual life,gestation-parturition,p16 and HPV situation was analyzed by corresponding statistical methods.Result1.Among the 135 CIN1 patients collected in this study,the oldest age was 65 and the youngest age was 21.Except for 4 cases without p16 test,73 cases(54.1%)were negative and58 cases(43.0%)were positive in the p16 test.79(58.5%)had their first sexual life under the age of 21 while 56(41.5%)over the age of 21.The minimum number of sexual partners was1 and the maximum number was 4.The lowest number of gestation-parturition was 0,and the highest number was 9.Among the contraceptive methods,46 cases(34.1%)were non contraceptive.2.After cluster analysis of symptoms,signs,tongue veins and other variables of 135CIN1 patients,it is finally concluded that CIN1 syndrome types are damp-heat syndrome,spleen-deficiency syndrome,kidney-deficiency syndrome,heat-toxin accumulation syndrome and yin-deficiency with dampness syndrome.Their distribution situation is damp-heat syndrome(37.0%),spleen-deficiency syndrome(27.4%),kidney-deficiency syndrome(20.7%),heat-toxin accumulation syndrome(7.4%),and yin-deficiency with dampness syndrome(7.4%).According to the classification of disease nature,there were 60 cases of excess syndrome(44.4%),65 cases of deficiency syndrome(48.2%),and 10 cases of syndrome of intermingled deficiency and excess(7.4%).3.Through the HPV survey of CIN1 patients,it was found that HPV16,18,and 52 infection were the most common infection types in CIN1,and CIN1 was mainly infected by single infection and high-risk infection type.4.There was a correlation between age and various syndrome types of CIN1(P<0.05),and the patients with kidney deficiency syndrome was significantly older than those with spleen deficiency syndrome and damp-heat syndrome.There was a correlation between the gestation-parturition number and various CIN1 syndrome types(P < 0.05),and the number of gestation and parturition in the patients with kidney-deficiency syndrome was significantly higher than those with damp-heat syndrome and spleen-deficiency syndrome.There was no significant correlation between the number of sexual partners and CIN1 syndrome types(P >0.05)and also no significant correlation between p16 among different syndrome types(P >0.05).5.There was no significant correlation between the number of HPV infection and CIN1 syndrome types(P > 0.05),neither was for HPV infection type and CIN1 syndrome type(P >0.05).Conclusion Conclusions of this study:1.The common clinical syndromes of CIN1 patients are damp-heat syndrome,spleen-deficiency syndrome,kidney-deficiency syndrome,heat-toxin accumulation syndrome,and yin-deficiency with dampness syndrome,which damp-heat syndrome is the most common syndrome clinically.2.CIN1 patients with kidney-deficiency syndrome were older and had higher frequency of gestation and parturition.In clinical treatment,CIN1 patients with older age should pay attention to tonifying the kidney and avoiding the suffering from CIN1 kidney-deficiency syndrome through correct contraceptive education.3.It can be seen that HPV16,18 and 52 are the most common infection types in CIN1 from the results of this survey where the infection frequency of HPV16,18 and 52 is equal in a single type,while the high-risk type of infection is predominant among the compound infection.There is no correlation between the distribution of TCM syndrome types and HPV infection for CIN1 patients.Clinically,CIN1 patients cannot be differentiated according to the number and type of HPV infection.