| Objective:To observe the distribution of TCM syndrome types of chronic non-Atrophic gastritis,and to explore the relationship between TCM Syndrome types of chronic non-Atrophic gastritis and serum pepsin,so as to provide reference index for TCM Syndrome differenti.Means:The study was divided into two parts.In the first part,a total of 379 patients with chronic non-atrophic gastritis who visited the department of Spleen and Stomach Diseases and inpatients of Zhangzhou Hospital of Traditional Chinese Medicine from January 1,2021 to December 31,2021 and met the inclusion criteria were collected through a cross-sectional study method.The information of four diagnoses was collected,and the syndrome types were determined,so as to obtain the distribution rules and differences of syndromes.In the second part,serum pepsinogen was detected in patients,and the collected serum pepsinogen was analyzed by medical statistics to explore the difference of serum pepsinogen levels in patients with different syndromic types of chronic non-atrophic gastritis.Result:1.A total of 379 patients with chronic non-atrophic gastritis were collected in this study,including 155 males and 224 females,with a male-female ratio of 1:1.45.The age of patients ranged from 18 to 80,with an average age of 51.The number of patients aged 50-59 was the largest,accounting for 32.2%.The mean course of disease was 3 months,<1 year was the most,accounting for 63.1%;HP positive in 133 cases,HP negative in 246 cases,HP infection rate 35%.2.The main symptoms of Traditional Chinese medicine are high frequency of loss of appetite or postprandial distention,stomach swelling and pain,and hidden pain in the stomach and spleen.Secondary symptoms with a higher frequency are acid reflux,belching,loose stools,fatigue and laziness,dry mouth or bitter mouth,fatigue and fatigue,and burning abdomen.The higher frequency of tongue is light red tongue,thin white moss,thin yellow moss,and the higher frequency of pulses is fine veins,chord veins,string slip veins,and fine chord veins.3.The distribution of TCM syndromes of chronic non-atrophic gastritis was from high to low: spleen-deficiency syndrome(32.19%)>damp-heat syndrome of spleen and stomach(28.23%)> disharmony between liver and stomach(25.86%)>cold and heat syndrome(10.29%)>deficiency and cold syndrome of spleen and stomach(3.43%).There was statistical significance in the distribution of TCM syndrome types of chronic non-atrophic gastritis in drinking patients(P<0.05).The distribution of TCM syndromes in drinking patients was from high to low: dampness-heat syndrome of spleen and stomach(56.7%)>disharmony between liver and stomach(23.3%)>qi deficiency syndrome(16.7%)>cold and heat syndrome(3.3%)>deficiency cold of spleen and stomach(0%).Patients with dampness-heat syndrome of spleen and stomach drinking were significantly higher than those without drinking(P<0.05).Gender,age,course of disease,HP infection and smoking had no significant difference in TCM syndrome type distribution of chronic non-atrophic gastritis(P>0.05).4.The levels of PGⅠ and PGⅡ in HP positive patients were higher than those in negative patients,but the ratio of PGR was on the contrary,the difference was statistically significant(P< 0.05).The level of PGR in smoking patients was higher than that in non-smoking patients,the difference was statistically significant(P<0.05).There was no significant difference between smoking and serum PGⅠ and PGⅡlevels(P>0.05).The PGⅠ and PGR in drinking patients were higher than those in non-drinking patients,the difference was statistically significant(P<0.05).There was no significant difference in the level of PGⅡ(P>0.05).Gender,age and course of disease had no significant difference in serum PG level distribution(P>0.05).5.There was statistical significance in serum PG level in TCM syndrome type distribution of chronic non-atrophic gastritis(P<0.05).Serum PGⅠ level: dampness-heat of spleen and stomach syndrome,disharmony of liver and stomach syndrome were higher than cold and heat syndrome,deficiency of spleen and stomach syndrome,deficiency of spleen and stomach cold syndrome,the difference was statistically significant(P<0.05).Spleen-qi deficiency syndrome and spleen-stomach deficiency cold syndrome were lower than the other three syndromes,and the difference was statistically significant(P<0.05).The serum PGⅡlevel of qi deficiency syndrome was lower than that of dampness-heat syndrome of spleen and stomach,disharmony syndrome of liver and stomach,mixed syndrome of cold and heat and deficiency cold syndrome of spleen and stomach,and the difference was statistically significant(P<0.05).The level of serum PGR in spleen-stomach dampness-heat syndrome was higher than that in the other four syndromes,the difference was statistically significant(P<0.05);the spleen-stomach deficiency cold syndrome was lower than that in the other four syndromes,the difference was statistically significant(P<0.05);the liver-stomach discordancy syndrome was higher than that in spleen-stomach deficiency syndrome,the difference was statistically significant(P<0.05).Conclusion:1.The TCM syndromes of chronic non-atrophic gastritis include deficiency of spleen-qi syndrome,damp-heat syndrome of spleen and stomach,disharmony between liver and stomach,cold and heat syndrome,deficiency and cold syndrome of spleen and stomach.The number of patients with qi deficiency syndrome was the largest,and the number of patients with spleen and stomach deficiency cold syndrome was the least.2.According to statistical analysis,the TCM syndrome type of chronic non-atrophic gastritis was related to the distribution of serum pepsinogen level.The level of serum PGⅠ in spleen-stomach dampness-heat syndrome and liver-stomach disharmony syndrome were significantly higher than those in other syndromes,while spleen-stomach deficiency syndrome and spleen-stomach deficiency cold syndrome were significantly lower than those in other syndromes.Although there was no difference in the distribution of dampness-heat of spleen and stomach and disharmony between liver and stomach in serum PGⅠ level,the distribution of dampness-heat of spleen and stomach was higher than that of disharmony between liver and stomach,and the distribution of deficiency of spleen and stomach was higher than that of deficiency of spleen and stomach in serum PGR.The level of serum PGⅡwas the lowest in spleen-qi deficiency syndrome,the level of PGR was the highest in dampness-heat syndrome of spleen and stomach,and the lowest in deficiency cold syndrome of spleen and stomach.The detection of serum PG may provide a theoretical reference for TCM syndrome differentiation and classification. |
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