| Objective: To observing the efficacy and safety of Jiawei Xixin Decoction in the treatment of cognitive impairment after ischemic stroke of phlegm turbidity and orifices type,to further explore the mechanism of Jiawei Xixin Decoction in the treatment of cognitive impairment after ischemic stroke of phlegm turbidity and orifices type,so as to provide medication guidance in clinic in the future.Methods: In strict accordance with the inclusion criteria and exclusion criteria,60 patients with cognitive impairment after ischemic stroke with phlegm turbidity and orifices in the Rui kang Hospital Affiliated to Guangxi University of traditional Chinese Medicine were randomly divided into control group and observation group,with 30 cases in each group.Both groups were treated with secondary prevention of stroke and donepezil hydrochloride tablets.The observation group was treated with Jiawei Xixin Decoction on the basis of the control group for a total of 28 days.Before and after treatment,cognitive function simple intelligent mental state scale(MMSE),activity of daily living scale(ADL),Montreal Cognitive assessment(Mo CA)and TCM syndrome score were carried out,At the same time,before and after treatment,blood routine,urine routine,stool routine,liver and kidney function,electrolyte,blood lipid,coagulation function,ECG and other examinations were carried out,and the adverse reactions during treatment were recorded through spss260 to sort out the data and evaluate the efficacy and safety of drugs.Results: A total of 60 patients were included in this study.During the treatment period,one patient in the control group fell off due to loss of followup,and one patient in the observation group took the initiative to withdraw from the test after one week of treatment because it was difficult to accept the taste of traditional Chinese medicine.Finally,a total of 58 patients were included in this study,29 in the control group and 29 in the observation group.1.Before treatment,the basic data of the two groups were statistically analyzed,and the difference was not statistically significant(P > 0.05),which was comparable.2.Before treatment,the scores of MMSE,Moca,ADL and TCM Syndrome Scale of the two groups were statistically analyzed.The difference was not statistically significant(P > 0.05).3.After treatment,the MMSE score of the two groups was higher than that of the same group before treatment,and the difference was statistically significant(P < 0.05).The MMSE score of the observation group was higher than that of the control group.After treatment,the difference between the two groups was statistically significant(P < 0.05).4.After treatment,the MOCA score of the two groups was higher than that of the same group before treatment,and the difference was statistically significant(P < 0.05).The MOCA score of the observation group was higher than that of the control group.After treatment,the difference between the two groups was statistically significant(P < 0.05).5.After treatment,the ADL score of the two groups decreased compared with that of the same group before treatment,and the difference was statistically significant(P < 0.05).The decrease of ADL score in the observation group was higher than that in the control group.After treatment,the difference between the two groups was statistically significant(P < 0.05).6.After treatment,the TCM syndrome score of the two groups decreased compared with that of the same group before treatment,and the difference was statistically significant(P < 0.05).The decrease of TCM syndrome score in the observation group was higher than that in the control group.There was statistically significant difference between the two groups after treatment(P <0.05).7.Clinical efficacy of MMSE scale: the effective rate of the control group was51.75%,and that of the observation group was 72.41%,The effective rate of the observation group was significantly higher than that of the control group(P< 0.05).8.Clinical efficacy of MOCA scale: the effective rate of the control group was55.17%,and that of the observation group was 75.86%,The effective rate of the observation group was significantly higher than that of the control group(P <0.05).9.Clinical efficacy of ADL scale score: the effective rate of the control group was 41.38%,and that of the observation group was 68.97%,The effective rate of the observation group was significantly higher than that of the control group(P < 0.05).10.Clinical efficacy of TCM Syndrome Scale: the effective rate of the control group was 62.07%,and that of the observation group was 82.75%.The effective rate of the observation group was significantly higher than that of the control group(P < 0.05).11.Safety index results: after treatment,the patients in both groups were rechecked for blood routine,liver and kidney function,electrolyte,coagulation function,blood lipid and ECG.Compared with the results before treatment,there were no obvious abnormalities,and the patients had no obvious adverse reactions during treatment.Conclusion: Jiawei Xixin decoction combined with donepezil hydrochloride is better than donepezil hydrochloride tablets in improving the cognitive level,activities of daily living and TCM Syndromes of patients with cognitive impairment after ischemic stroke of phlegm turbidity and orifices type.It is safe and worthy of promotion. |
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