Objective: The purpose of this study is to treat early and middle stage knee osteoarthritis of wind cold and dampness bi syndrome by applying Quhan chubi Decoction.The subjective and objective evaluation scale was used to more comprehensively verify the clinical efficacy and safety of relieving joint pain,improving range of motion and TCM symptoms.To determine its clinical application value.Methods: By collecting patients treated in outpatient and inpatient departments of Dongge And Xianhu Hospitals of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from March 2021 to December 2021,70 patients with early and middle stage knee osteoarthritis of wind cold and dampness bi syndrome were selected and met the inclusion criteria.According to simple random allocation,35 cases were divided into control group and observation group.The control group was given Etocaoxi tablet plus basic treatment(health education and exercise therapy),and the observation group was given Quhan chubi Decoction.plus basic treatment(health education and exercise therapy),the course of treatment was 4weeks.VAS pain score,WOMAC score,TCM syndrome score and adverse reactions of the two groups were observed before treatment,2 weeks after treatment,4 weeks after treatment respectively.To conduct a comprehensive assessment,SPSS20.0 was used for data processing and analysis.Results: A total of 70 patients included in this study,During the experiment,2 cases in the control group were excluded,and finally 33 cases in the control group and 35 cases in the observation group were included in the results analysis.There was no significant difference in general information(gender,age,body mass index,disease course and disease location)between the two groups(P>0.05),indicating comparability.There was no significant difference between the two groups before treatment(VAS score,WOMAC score and TCM syndrome score)(P>0.05),indicating comparability.The comparative analysis between and within the two groups after treatment is as follows:1.VAS pain score:(1)Intra-group comparison: VAS scores in both groups decreased significantly after treatment compared with before treatment(P<0.01).(2)Comparison between groups: There was no significant difference between the two groups(P2 week,4 week > 0.05)after 2 weeks and 4 weeks of treatment,indicating that the two groups had the same effect on pain relief.2.WOMAC score:(1)Intra-group comparison: After treatment,the internal pain,stiffness,daily activities and total scores of the two groups were significantly lower than those before treatment(P<0.01).(2)Comparison between groups: There was no significant difference in pain between the two groups after 2 and 4 weeks of treatment(P>0.05 after 2 and 4 weeks of treatment).There were no significant differences in stiffness,daily activity and total score between the two groups after 2 weeks of treatment(P>0.05 after 2 weeks of stiffness,2 weeks of daily activity and total score after 2weeks of treatment).However,after 4 weeks of treatment,there were statistically significant differences in stiffness and daily activities between the two groups(P<0.05 after 4 weeks of stiffness and daily activities),and significant differences in total scores(P<0.01 after 4 weeks of treatment).The observation group was significantly better than the control group,and the clinical efficacy of the observation group was more prominent.3.TCM syndrome score:(1)Intra-group comparison: The scores of TCM syndromes in both groups were significantly lower after treatment than before,and the difference was significant(P<0.01).(2)Comparison between groups: There was no statistically significant difference between the two groups after 2 weeks of treatment(P2 week<0.05),However,after 4 weeks of treatment,the observation group was significantly better than the control group,and the difference was statistically significant(P4 week<0.05).4.Comparison of total curative effects of diseases: The total effective rate of the observation group was 97.14%,and the total effective rate of the control group was 84.85%.According to the rank sum test,P=0.02<0.05 was statistically significant.5.Comparison of total curative effects of TCM syndromes: The total effective rate of the observation group was 94.29%,and the total effective rate of the control group was 81.82%.According to the rank sum test,P=0.007<0.05 was statistically significant.Conclusion: 1.In the treatment of early and middle stage knee osteoarthritis of wind cold and dampness bi syndrome,Quhan chubi Decoction can relieve knee joint pain,improve knee joint activity function and improve the overall quality of life to a certain extent.2.The combination of Quhan chubi Decoction is suitable and the clinical efficacy is reliable.It has definite efficacy in improving VAS score,WOMAC score and TCM syndrome score of wind cold and dampness bi syndrome early and middle stage knee osteoarthritis.3.In the process of this trial,no obvious complications or adverse reactions occurred in the enrolled patients,indicating that the formula has a low incidence of adverse reactions and is an effective prescription with good effect and high safety,which has clinical application value and is worthy of further promotion. |