| Objective: In order to determine the optimal ventricular rate control interval for patients with Qi-Yin deficiency syndrome of atrial fibrillation,the TCM syndrome performance、sleep quality and quality of life of patients under different ventricular rate control were compared to explore which ventricular rate control interval let patients feel more comfortable.Methods: A total of 101 patients with long-term persistent atrial fibrillation and permanent atrial fibrillation(deficiency of Qi-Yin Syndrome)in the Affiliated Hospital of Shandong University of traditional Chinese medicine from August 2020 to December 2021 were selected.According to the average ventricular rate of 24 h ambulatory electrocardiogram,they were divided into low ventricular rate group(< 80 beats / minute)and high ventricular rate group(80 ～ 110 beats / minute),including 51 cases in low ventricular rate group and 50 cases in high ventricular rate group.After the patients agreed and signed the informed consent form,the researchers collected their age,gender,height,weight,duration of atrial fibrillation,combined diseases,blood glucose and blood lipid(Glu,TG,TC,HDL,LDL),coagulation indexes(PT,PTA,APTT,FIB,TT),24 h ambulatory ECG and current drugs.The diagnostic scale of palpitations,Qi-Yin deficiency syndrome,pittsburgh sleep quality index(PSQI)and atrial fibrillation effect on quality-oflife(AFEQT)questionnaire were completed in the form of question and answer.The above data were entered into SPSS 25.0 statistical software,and the current situation was analyzed by chi square test,nonparametric test,t-test and other statistical methods.Results: There were no significant differences in gender composition,age distribution,disease duration and BMI between 2 groups(P > 0.05),indicating comparability.In the two groups of patients with hypertension,there were 38 of 51 patients(70.6%)in the low ventricular rate group and 32 of 50 patients(60.0%)in the high ventricular rate group.In patients with diabetes mellitus,there were 19 of 51 patients(37.3%)in the low ventricular rate group and 13 of 50 patients(28.0%)in the high ventricular rate group.For patients with coronary heart disease,there were 33 of 51patients(64.7%)in the low ventricular rate group and 28 of 50 patients(56.0%)in the high ventricular rate group.In patients with heart failure,there were 9 of 51 patients(17.6%)in the low ventricular rate group and 12 of 50 patients(24.0%)in the high ventricular rate group.There were no significant differences in blood glucose,lipid and coagulation indexes between 2 groups(P > 0.05).TCM syndromes: The TCM syndromes score of patients in the low ventricular rate group was lower than that in the high ventricular rate group,and the difference was statistically significant(P < 0.05).The low ventricular rate group showed lighter Qi-Yin deficiency as a whole.In terms of sleeping quality,there was no statistical significance between the two groups in subjective sleeping quality score、time for falling sleep score、sleep time score、sleep efficiency score、sleep disorders score、use of sleep medications score、daytime dysfunction score and total scores(P > 0.05).The actual sleep efficiency of high ventricular rate group was higher than that of low ventricular rate group,the difference was statistically significant(P < 0.05),and there was no significant difference between the two groups in the actual time for falling sleep and the actual sleep time(P > 0.05).In terms of quality of life,there were no statistically significant differences between the two groups in the scores of symptoms,daily activities,treatment concerns and the total score of quality of life(P > 0.05).In the two groups of patients taking new oral anticoagulants,the daily activity score of low ventricular rate group was higher than that of high ventricular rate group,the difference was statistically significant(P < 0.05),but there was no statistical significance in symptom,treatment concerns and total score of quality of life(P > 0.05).There were no significant differences in symptom,daily activity,treatment concerns and total score of quality of life between the two groups taking β blockers(P >0.05).Conclusion: For patients with long-term persistent atrial fibrillation and permanent atrial fibrillation(deficiency of Qi-Yin Syndrome),controlling the ventricular rate less than80 beats / minute could make patients have lighter TCM syndrome performance,and patients taking new oral anticoagulants had better performance in daily activities.Controlling the ventricular rate at 80 ～ 110 beats / minute could improve the actual sleep efficiency of patients.Different ventricular rate control levels would not affect the sleeping quality and quality of life of patients with atrial fibrillation. |
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