Expression Of Eosinophils In Schistosomiasis Colorectal Cancer And Its Clinical Significance

Objective:To investigate the expression of eosinophils in schistosomiasis colorectal cancer tissues and its correlation with clinical characteristics,and to analyze the expression of tissue-associated eosinophils in schistosomiasis colorectal cancer and nonschistosomiasis colorectal cancer.Whether there is difference in expression and analysis of the effect of this difference on prognosis.Methods:1.This topic will collect a total of 587 colorectal cancer patients admitted to our hospital from January 2018 to December 2019,including 78 patients with schistosomiasis colorectal cancer and 509 patients with non-schistosomiasis colorectal cancer.The basic medical history(sex,age)and clinicopathological characteristics of each colorectal cancer patient were collected.2.The collected schistosomiasis colorectal cancer cases and non-schistosomiasis colorectal cancer cases were separately grouped by clinicopathological factors(age,gender,depth of tumor invasion,lymph node metastasis,degree of differentiation),and then tissue correlation was performed under light microscopy.Count of sex eosinophils,and analyze the correlation between the expression level of tissue-associated eosinophils in colorectal cancer tissues and clinicopathological factors.3.The above two groups of cases were sampled by stratification according to the distribution of age,tumor stage and degree of differentiation,and 10-30 cases were selected from the schistosomiasis colorectal cancer patient group and the nonschistosomiasis colorectal cancer patient group for tissue-associated eosinophilia.Comparison of expression levels.4.Collected inpatients who received colonoscopy biopsy in our hospital during the same period and were diagnosed with colitis and colorectal adenoma with schistosomiasis egg deposition,and were divided into schistosomiasis enteritis group,schistosomiasis adenoma group and normal tissue(selected here).Non-metastatic distal tissue),count eosinophils in tissue,and then compare the number of eosinophils with schistosomiasis colorectal cancer to analyze whether there is a difference in the expression level of tissue eosinophils.5.Finally,organize the data,use the relevant statistical software to perform the chi-square test and the independent sample t test,and draw the conclusion.Results:Clinicopathological data:Among the 587 colorectal cancer patients,78(13.3%)had schistosomiasis colorectal cancer,509(86.7%)had schistosomiasis colorectal cancer,schistosomiasis colorectal cancer and nonschistosomiasis colorectal cancer The clinicopathological data of cancer patients showed that the average age of the schistosomiasis colorectal cancer group was higher than that of the non-schistosomiasis colorectal cancer group,and the majority of patients aged≥65 years had a statistically significant difference(P=0.005).In terms of gender distribution,there were more males than females in both groups,but the proportion of males in the schistosomiasis colorectal cancer group was higher than that in the non-schistosomiasis group(P=0.003).There was no statistical significance(P=0.785),and in terms of tumor staging,the proportion of patients with schistosomiasis T3-4 was higher than that of the non-schistosomiasis group(P=0.000),and there was no significant difference in lymphatic metastasis(P=0.625).The number of tissue-related eosinophils:the expression of eosinophils in the tissues of schistosomiasis colorectal cancer patients and non-schistosomiasis colorectal cancer patients was not related to age and gender(P>0.05),and was not related to the depth of tumor invasion,lymph node metastasis,The degree of differentiation was related(P<0.05).In normal tissue,schistosomiasis colitis group,schistosomiasis adenoma group and schistosomiasis colorectal cancer group,the expression of eosinophils was significant in adenoma,less in adenocarcinoma,intermediate in enteritis group,distal The tissue was rare,and the number of eosinophils in the tissue decreased significantly during thetumorcancer transition(t=5.718,P=0.000).The expression of eosinophils in schistosomiasis colorectal cancer group and nonschistosomiasis colorectal cancer group was significantly higher than that in nonschistosomiasis colorectal cancer in well differentiated,T1-2 stage and without lymph node metastasis.(P<0.05),there was no significant difference between the two in the middle and low differentiation,T3-4 stage,and lymph node metastasis(P>0.05).Conclusion:1.Schistosomiasis colorectal cancer is more common in elderly men,suggesting that in schistosomiasis endemic areas,elderly people need to pay more attention to digestive tract physical examination.2.The presence or increase of tissue-associated eosinophils is correlated with the severity of the disease,suggesting that it may be related to the prognosis.3.The differential expression of tissue-associated eosinophils at different stages of intestinal schistosomiasis may be useful in stratifying patients at increased risk for future adenocarcinoma and in selecting patients for more aggressive and frequent endoscopic monitoring.