Study On Viscera Pathological Changes Of Polycystic Ovary Syndrome Based On Clinical Data Mining

Objective: The etiology and pathogenesis of Polycystic ovarian syndrome(PCOS)and its evolution trend were analyzed by bibliometric analysis and other methods,and the pathological changes of kidney,liver and spleen organs of PCOS were revealed by comprehensive analysis of clinical case data from multiple perspectives.Methods: 1.Based on "syndrome of polycystic ovary syndrome OR syndrome type OR syndrome differentiation of polycystic ovary syndrome OR PCOS syndrome OR syndrome differentiation of PCOS",the literatures in the last ten years were searched.In this paper,time series analysis method,syndrome frequency statistics of related literature and keyword measurement method were used to analyze the research on PCOS viscera and syndrome at different levels,and the cognitive changes and development trend of the etiology and pathogenesis of PCOS were analyzed.2.PCOS Case Report Form(CRF)was designed based on the definition and quantification of the four-diagnosis information in literature.Referring to likert and other classical scales,the PCOS symptom list words were extracted,and the CRF table structure and item pool of PCOS were preliminatively determined.After that,symptom items were screened by discriminative analysis method,factor analysis method,correlation coefficient method and Kronbach coefficient method,and the reliability of THE CRF table was tested by homogeneity reliability and split reliability.Surface validity,convergence validity and structure validity were used to test the validity of CRF table.3.All clinical cases of PCOS in both regions were collected.From January 2019 to June2021,263 cases of PCOS were collected offline in the Reproductive and Genetic Center of Integrated Traditional Chinese and Western Medicine of The Affiliated Hospital of Shandong University of Traditional Chinese Medicine and the Outpatient Department of Gynecology of Shandong Tai ’an Hospital of Traditional Chinese Medicine,and symptom and endocrine detection index databases were established respectively.SPSS Statistics 20.0and SPSS Modeler 18.0 were used for systematic cluster analysis,Bayesian network TAN model analysis and association rule globe graph and Apriori algorithm analysis.Results: 1.The time series analysis model formula was determined as Y(t)=7.582-1.0*ε(t-1),and the increasing trend of literature quantity and hot spot prediction were obtained in the next five years.Through the statistics of syndrome frequency in 645 literatures,a total of 21 TCM syndromes of PCOS were found,among which phlegm-dampness syndrome,kidney deficiency and blood-stasis syndrome,kidney qi deficiency syndrome,kidney deficiency and liver stagnation syndrome and spleen deficiency and phlegm-dampness syndrome were the most frequent.In terms of keyword econometrics,a total of 42 effective keywords were screened out and systematically divided into 7 categories,among which the keywords "insulin resistance","infertility" and "sex hormone" were the most popular,which to some extent reflected the complexity and research enthusiasm of PCOS viscera syndrome.2.Bayesian network analysis showed that there were significant differences in the importance of endocrine detection indexes between the effective and invalid cases of PCOS.Among the effective PCOS cases,the most important endocrine detection variable was serum Luteinizing hormone(LH),which reached 0.34,and the least important was follicle-stimulating hormone(FSH).Probability is 0.07;FSH was the most important test index in PCOS invalid cases,up to 0.34.The least important was progesterone(P)at 0.09.3.Syndrome research shows that different age groups have their own characteristics,15-21 years old group is mostly spleen and kidney deficiency syndrome,22-28 years old group is mostly kidney deficiency syndrome,29-35 years old group is mostly liver and kidney Yin deficiency syndrome,36 years old and above group is mostly liver stagnation syndrome,lesions of the viscera around the spleen,kidney and liver three viscera related symptoms change.The syndromes of invalid cases in different age groups were liver and kidney Yin deficiency syndrome,kidney deficiency phlegm and stasis syndrome,liver and kidney Yin deficiency syndrome and kidney deficiency phlegm and stasis syndrome and liver and kidney Yin deficiency syndrome.Conclusions: 1.The research on the syndromes of PCOS viscera is gradually deepening and complicating,and the combination of PCOS viscera lesions and insulin resistance and other modern studies is becoming more and more closely,forming a research hotspot.2.From the perspective of efficacy correlation analysis,more attention should be paid to the role of FSH in the clinical efficacy evaluation of PCOS.3.In the early stage,PCOS is mainly characterized by deficiency of spleen and kidney and gradually involving liver and kidney,while in the later stage,it is mainly characterized by liver stagnation and qi stagnation,suggesting that PCOS may be characterized by "spleen-kidney-liver and kidney" lesions and viscera lesions accompanied by gradual aggravation of liver depression.The incidence trend of PCOS may change from congenital to simultaneous.