| Objective: To compare and study the dosing regimens for type 2 diabetes patients with different early detection data in internal medicine of endocrinology in a certain hospital,to explore the correlation between laboratory indexes and different dosing regimens,to predict whether the general data of patients and various laboratory indexes obtained by pre-treatment test can be referred,whether the basis can be provided for formulating individual medication regimens of patients,and to explore the relevant clinical diagnosis and treatment guidelines for the efficacy comparison of dapagliflozin,metformin,acarbose and insulin as treatment drugs for type 2 diabetes.To study the scientificity of drug usage and dosage and conduct pharmaceutical care for patients,the probability of adverse reactions of patients is significantly reduced,and the safe and efficient medication of patients is maintained.Methods: A total of 543 inpatients in the Department of Endocrinology from January 2020 to December 2021 were selected,and 319 cases met the inclusion criteria.The general information of the patients,the test indicators before and after treatment and drug use were recorded.In this study,the patients were divided into four dosing regimens according to their medication conditions: the first insulin monotherapy group,the second insulin combined with acarbose treatment group,the third insulin combined with metformin treatment group,and the fourth insulin combined with Dapagliflozin treatment group.Data were input into SPSS 26.0software for analysis,and p<0.05 was considered to be statistically significant.Results:1.The results of comparative analysis of medication regimen indicators of patients with type 2 diabetes in the fourth group showed that the average BMI value in this group was 27.33±3.92,which was relatively high compared with other groups.The median TG value in Group 3 was 2.14(1.12-4.10),which was relatively high compared with the other groups.The mean HDL-C value in Group 4 was 1.07±0.32,which was relatively low compared with other groups.As shown in p<0.05,the difference was statistically significant.2.Comparison and analysis of various laboratory indicators of the dosing regimen between each two groups showed that the TG value in group 3 was 2.14(1.12–4.10)higher than 1.87(1.30–3.25)in the four groups.The mean HDL-C value in Group 4was 1.07±0.32 lower than 1.12±0.28 in Group 3(p<0.05).3.The result of that comparative analysis of the change value of the blood glucose indexes of the type 2 diabetic patient after treatment show that,in RBG,the change value of 6.00(2.70–10.75)in group 4 after treatment was significantly lower than1.55(-1.95–5.45)in group 2(p<0.05),and the difference was statistically significant.Conclusion: According to the comparison and analysis of various laboratory indexes of patients with type 2 diabetes before treatment with different dosing regimens,the results showed that BMI,TG and HDL-C indexes could be used for reference in formulating individualized dosing plan for type 2 diabetes.According to the results,insulin+Dapagliflozin dosing scheme is recommended for patients with high BMI and low HDL-C value in type 2 diabetes,and insulin+metformin dosing scheme is recommended for patients with high TG value.The combined regimen of insulin and Dapagliflozin significantly reduced RBG values.The results of this study showed that BMI,TG,and HDL-C indicators were conducive to the development of individual dosing regimen for patients,and Dapagliflozin had the effects of reducing body weight,regulating blood glucose,and improving cardiac and renal function.The study results showed that the BMI,TG,HDL-C indicators help to patients develop individualized dosage regimen. |
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