| Objective To observe the effect of dapagliflozin in patients with diabetic nephropathy(DN),discuss its renoprotective effect and mechanism in early DN.Methods Selected the outpatients and inpatients of the second affiliated hospital of Chongqing medical university as the research subjects.Finally thirty new-onset type 2 diabetes mellitus(T2DM)patients,50 diabetic nephropathy(DN)patients were involved in this study,and thirty healthy subjects were involved in as normal glucose tolerant(NGT).The T2 DM and DN groups were treated with Dapagliflozin 10mg/day for 12 weeks,and the curative effect was analyzed.Results After treatment with dapagliflozin,blood glucose,HbA1 c,body weight and blood pressures in T2 DM and DN groups were reduced(both P<0.05).In addition,The values of estimated glomerular filtration rate(eGFR)was slight decrease in both two groups(P<0.05).The urinary albumin/creatinine ratio(UACR)level was decreased in DNgroup(P<0.05).The levels of monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)was significantly higher than those in NGD group when into this study,and had significant reduction after dapagliflozin therapy(all P<0.05).Conclusion Dapagliflozin therapy can reduce urine microalbumin in DN patients of early stage,and this change is independent of the decrease in blood glucose,blood pressure,and body weight,and shows a positive correlation with the decrease of pro-inflammatory cytokines.which probably directly related with reduction of serum proinflammatory cytokines.Thus,dapagliflozin has a direct protective effect on the kidney,and its mechanism may be related with the reduction of serum pro-inflammatory cytokines levels. |
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