Clinical Efficacy Of Qufeng Ningfei Powder In The Treatment Of Children With CVA And Analysis Of The Pathogenesis Factors Of Children With CVA

Research purposes:Children with cough variant asthma were randomly divided into two groups,the treatment group was given Qufeng Ningfei powder,and a prospective control study was conducted with the control group with pure western medicine to prove that Qufeng Ningfei powder can improve the clinical efficacy of CVA in children,then open up new ideas and new methods for Chinese medicine diagnosis and treatment of children’s CVA.At the same time,compared the children with CVA with the normal children,the logistic regression model was used to study the possible influencing factors,which provided a theoretical basis for the prevention and management of the disease.Research methods:The first part is a prospective,randomized,and controlled research design.Children with CVA who have been treated in outpatient clinics in our hospital since the beginning of time are the research objects.The treatment group was treated with Qufeng Ningfei Powder,and the control group was treated with oral montelukast sodium tablets and hydrochloric acid in the treatment of Procaterol tablets,the clinical efficacy and safety of Qufeng Ningfei Powder in the treatment of children’s CVA were determined by the improvement of the number of attacks and the degree of attacks of the main symptoms before and after treatment,and the changes of the TCM Syndrome Grading Quantitative Scale.In the second part,the CVA children who were treated in our hospital and the healthy children who came to our hospital for physical examination were taken as the research objects,and their data including gender,age,mode of production,feeding mode,body mass index,history of allergic rhinitis,and history of atopic dermatitis were collected,history of allergic conjunctivitis,history of repeated respiratory tract infections,history of asthma or chronic cough in parents of grades 1 and 2,atopic constitution of parents of grades 1 and 2,history of smoke exposure,history of keeping pets or planting flowers and plants at home,laying carpets and Some blood eosinophil counts,etc,then use logistic regression model to study and analyze the possible risk factors of CVA in children,and provide the basis for the prevention,home care and treatment of the disease.Research result:Part 1 Evaluation of the efficacy of Qufeng Ningfei Powder in the treatment of children with cough variant asthma1.1 General informationThere were 77 children in the income group,including 39 in the treatment group and 38 in the control group.In terms of gender composition,there were 27 male children in the treatment group,accounting for 69.2%,and 12 female children,accounting for 30.8%.in the control group,there were 23 male children,accounting for 60.5%,and 15 female children,accounting for 39.5%.There were no statistically significant differences between the two groups in age,course of disease and syndrome scores before treatment(P>0.05),which were comparable.1.2 Score analysis of main TCM syndromes between groups after treatmentOn the 7th day after treatment,the difference in cough frequency and runny nose between the two groups was statistically significant(P<0.05).on the 14th day after treatment,the difference in cough frequency between the two groups was statistically significant(P<0.05).Academic significance(P<0.05).This shows that Qufeng Ningfei Powder is better than pure western medicine in relieving cough symptoms in children.1.3 Analysis of main syndrome scores in the group before and after treatmentThere were statistically significant differences in TCM syndrome scores such as cough frequency,cough degree,expectoration,sneezing,nasal congestion,runny nose and total score between the two groups of children before and after treatment(P<0.05),indicating that Qufeng Ningfei powder in the treatment group and montelukast sodium combined with procaterol hydrochloride in the control group were both effective.1.4 Comparison of the difference between the two groups of children before and after treatmentThe difference between the two groups of children’s main syndrome scores before and after treatment was compared between the two groups,and there were statistically significant differences in the number of coughs and the degree of coughing and the total score of TCM syndromes at 7 and 14 days after treatment(P<0.05),which indicated that Qufeng Ningfei San was better than montelukast sodium combined with procaterol hydrochloride in improving cough symptoms and TCM syndrome scores in children.1.5 Comparison of the total effective rate between the two groups of childrenAfter the rank sum test of graded data,the total effective rate of the treatment group was 94.87%,and that of the control group was 78.95%.The difference in the total effective rate between the two groups was statistically significant(P<0.05).The clinical efficacy of Qufeng Ningfei powder is better than that of montelukast sodium combined with procaterol hydrochloride.Part 2 Analysis of pathogenic factors of cough variant asthma in children2.1 General informationA total of 77 children with CVA and 77 healthy children were included in this study.Among the 77 children in the observation group,there were 50 males and 27 females with an average age of 5.47±2.30,and 77 in the control group.Among the healthy children,48 were male and 29 were female,with an average age of 5.82±2.15.2.2 Univariate analysisAfter the univariate analysis of each pathogenesis-related factor,the conclusion was drawn:history of allergic rhinitis,history of atopic dermatitis,history of repeated respiratory tract infection,history of asthma/chronic cough in parents of grades 1 and 2,and atopic constitution of parents of grades 1 and 2,production methods,feeding methods,history of smoke exposure,pets/plants at home and peripheral blood eosinophils are associated with the incidence of cough variant asthma in children.2.3 Multivariate analysisAfter univariate analysis to eliminate irrelevant factors,the remaining 10 related factors were subjected to logistic regression analysis to obtain the results:children’s history of repeated respiratory tract infections,history of asthma and chronic cough in parents of grades 1 and 2,mode of production and peripheral blood eosinophilia Granulocyte count is a risk factor for CVA in children.Researh conclusion:From the first part of the study,it can be concluded that Qufeng Ningfei Powder is better than montelukast sodium combined with procaterol hydrochloride in the treatment of CVA in children.The degree of cough and other related TCM syndromes of the lung system,such as nasal congestion,runny nose and the total score of TCM syndromes,are worthy of further promotion and application in clinical treatment.From the second part of the study,it can be concluded that the related factors of childhood cough variant asthma are the history of recurrent respiratory tract infection,the history of asthma/chronic cough in parents of grades 1 and 2,the mode of production and peripheral blood eosinophil count,etc.The onset is the result of a combination of multiple factors.According to the results of this study,there is some guidance for clinical work,and attention should be paid to children with a family history of asthma;children with a history of repeated respiratory tract infections should pay attention to strengthening physical exercise,improving immune function and preventing respiratory tract infections;strengthening the propaganda of natural birth And in clinical work,attention should be paid to monitoring the peripheral blood eosinophil count of children,in order to reduce the incidence of children with cough variant asthma and achieve the goal of reducing the medical and economic burden on families and society.