| Objective: To investigate the relationship between polymorphism of angiotensin converting enzyme(ACE)gene I/D and susceptibility of coronary heart disease in primary hypertension patients,in order to realize personalized prevention and therapeutic intervention in cardiovascular disease patients.Methods: In this study,we used a retrospective controlled study and selected a total of 352 hospitalized patients from December 2018 to August 2020 in Nanning Second People’s Hospital,including 187 primary hypertension patients complicated with CHD,and 165 primary hypertension patients.All patients had performed Coronary angiography(CAG),according to the results of the CAG,we divided the patients in two groups,including case group(Coronary artery stenosis>50%,187 cases)and control group(primary hypertension patients,165cases).According to Gensini score we divided the case group into mild group(Gensini score<42,104cases)and severe group(Gensini score ≥42,83 cases).We detected the polymorphism of ACE gene by polymerase chain reaction(PCR),to analyze the relationship between ACE gene I/D polymorphism and primary hypertension patients complicated with CHD.Results: There was no statistical difference in the distribution of DD,ID and II genotypes among primary hypertension patients with or without CHD(P>0.05).There was no statistical difference in the distribution of DD,ID and II genotypes between mild and severe group(P>0.05).There was no statistical difference in the distribution of I/D alleles among patients with or without CHD(P>0.05).There was no statistical difference in the distribution of I/D alleles among patients between mild and severe group(P>0.05).Conclusion: In this study,there was no correlation between ACE I/D polymorphism and primary hypertension patients complicated with or without CHD,and no correlation between ACE I/D polymorphism and the severity of CHD in patients with primary hypertension. |
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