Association Of The 4G/5G Polymorphism In The Plasminogen Activator Inhibitor-1(PAI-1) Gene And The Insertion/deletion Polymorphism In The Angiotensin Iconverting Enzyme(ACE) Gene With The Coronary Artery Diseasse In Chinese

The coronary artery disease (CAD) is one of the most frequent causes of morbidity and mortality in modernized society. Both environmental and genetic factors contribute to the development of coronary artery disease and myocardial infarction. The conventional risk factors for CAD include hypertension, hyperlipidemia, diabetes mellitus, smoking and obesity. In recent years, the genetic factor has been studied as a potential risk factor for myocardial infarction and angina pectoris.Plasminogen activator inhibitor-1(PAI-1) is a key enzyme in regulation of fibrinolytic system. The impairment of the fibrinolytic capacity is one of the risk factors in CAD. There have been some conflicted results about the...