| Objective:To observe the clinical effect of Kuijiening enema on ulcerative colitis(damp-heat type)and its effect on serum level of relative cytokines,and to explore its possible mechanism.Methods:A total of 60 patients with ulcerative colitis who met the inclusion criteria in the outpatient department and ward of our hospital from November 2017 to November 2019 were randomly divided into 2 groups with 30 cases each.Both groups were given basic treatment,while the control group was given oral administration of mesalazine,the observation group was treated with Kuijiening enema combined with mesalazine.One week of treatment was taken as a course of treatment in both groups,with a total of eight courses of treatment.TCM symptom scores,Mayo scores,serum levels of IL-8 and IL-10,and safety indicators were recorded before and after treatment,and data were compiled and analyzed to analyze TCM symptom score,TCM syndrome effect,Mayo score,clinical efficiency,clinical remission rate,endoscopic response rate,mucosal healing rate,changes in serum levels of IL-8 and IL-10.Results:1.Mayo activity index:After treatment,the activity index of both groups decreased compared with the previous one,and the difference was statistically significant(P<0.01).The decrease in the observation group was more significant(P<0.05).2.Clinical efficacy:The clinical effective rate was 93.33%in the observation group and 83.33%in the control group,but the difference between the 2 groups was not statistically significant(P>0.05).The clinical remission rate was 60%in the observation group and 30%in the control group,with statistically significant difference(P<0.05).The endoscopic response rate of the observation group was 93.33%,and that of the control group was 80%,but the difference between the 2 groups was not statistically significant(P>0.05).The mucosal healing rate was 90%in the observation group and 66.7%in the control group,and the difference between the 2 groups was statistically significant(P<0.05).3.TCM symptom score:After treatment,the total scores of the two groups were significantly reduced(P<0.01).After treatment,the observation group was significantly better than the control group in reducing the total TCM symptom score,whose difference was statistically significant(P<0.01).4.Single TCM symptom score:After treatment,the symptom scores of both groups decreased(P<0.01),and there were statistically significant differences in improving symptoms of bloody purulent stool,abdominal pain and hot sensation in the anus between the 2 groups(P<0.05),while there was no statistically significant difference in improving symptoms of diarrhea,tenesmus,scanty dark urine,dry and bitter mouth and abdominal distention between the 2 groups(P>0.05).5.Efficacy of TCM syndromes:The total effective rate was 93.33%in the observation group and 80%in the control group,and the difference between the 2 groups was statistically significant(P<0.05).6.Laboratory indicators:After treatment,the serum levels of IL-8 in both groups decreased,while the serum levels of IL-10 increased,with statistically significant differences(P<0.01).After treatment,the reduction of IL-8 and the increase of IL-10 in the observation group were both significantly higher than those in the control group(P<0.01).7.Safety evaluation:No obvious adverse reactions and abnormal safety indicators were observed in the 2 groups.Conclusion:In the treatment of UC(damp-heat type),mesalazine combined with kuijiening enema has more advantages than mesalazine alone in improving symptoms of bloody purulent stool,abdominal pain and hot sensation in the anus,reducing the total score of TCM symptoms,improving the efficacy of TCM syndromes,reducing Mayo activity index,promoting clinical remission and mucosal healing,which may play an anti-inflammatory effect by increasing serum level of IL-10 and decreasing serum level of IL-8. |
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