Therapeutic Effect Of Complex Amino Acid And Probiotics On Feline Kidney Injury

With the rapid growth of the number of companion animals cats each year,the frequent Acute kidney injury(AKI)and Chronic renal failure(CKD)diseases have caused serious damage to the body health of pets,and commonly used western medicine in clinical treatment will have certain side effects.At present,there are a large number of studies that show that amino acids and probiotics have a significant improvement in renal function and no toxicity.However,the therapeutic effect on clinical pet kidney disease is still unclear,and it is necessary to conduct statistical analysis on the therapeutic effect,which can provide an important reference for the formulation of treatment plan,drug use and prevention and treatment of AKI and CKD in cats.From January 2021 to December 2022,the cases of AKI and CKD in cats admitted to 10 animal clinics in Beijing were statistically analyzed to summarize the incidence of AKI and CKD in cats in the region.Fifty AKI cats were divided into two groups,and the therapeutic effects of conventional infusion therapy and compound amino acid preparations combined with infusion therapy were compared.Cases of CKD were classified according to the classification criteria established by the International Association of Nephrology and divided into two,three and four cat groups.Patients were treated with conventional symptomatic therapy,conventional therapy+compound amino acid preparation and conventional therapy+compound probiotics preparation.During the treatment,clinical symptoms,renal function,related blood indexes,inflammation level,treatment cycle and outcome of each treatment group were recorded and statistically analyzed for comparative analysis to identify a good treatment,which would provide a powerful theoretical support for the effective treatment of cat renal failure in clinical practice.Case investigation of AKI in cats showed that the onset age of AKI was mainly from 1 to 5years old(69.7%),and the incidence rate was the highest at the age of 3 years old(42.6%).The incidence rate of American short-haired cats was the highest(24.5%),followed by Garfield and British short-haired cats.Postrenal factors accounted for the highest etiology,accounting for58.5%.The incidence in males was significantly higher than that in females,up to 83%.The most common case of CKD in cats was over 14 years old(38.8%).The incidence rate of American short-haired cat was the highest,accounting for 21%,followed by British short-haired cat and Chinese garden cat.The incidence in males was significantly higher than that in females,up to64.2%;Anemia accounted for the most complications,accounting for 26.2%;The most common clinical symptoms were anorexia,weight loss and polydipsia and polyuria.The majority of cases present with mild inflammation,44.6%.The results of adjuvant therapy of AKI and CKD show that for the treatment of AKI,conventional infusion can achieve good therapeutic effect,but adding compound amino acid preparation can not effectively improve the curative effect.For different grades of CKD,According to the results of renal function indexes and related blood indexes,the compound amino acid preparation could significantly improve the efficacy of secondary CKD(P<0.01),significantly enhance the treatment effect of tertiary CKD(P<0.05),but had little change in the treatment effect of quaternary CKD(P > 0.05),and significantly reduce the blood phosphorus concentration of cats with secondary and tertiary CKD,but the treatment cycle was longer than that of the compound probiotics preparation.The therapeutic effects of the composite probiotics on the secondary and tertiary CKD are very satisfactory(P<0.01),but the therapeutic effects on the fourth-stage CKD are not different from those of other treatments(P>0.05),and the composite probiotics can significantly improve the micro-inflammation status.