Correlation Analysis Of PLR,NLR And Type 2 Diabetes Complicated By Carotid Atherosclerotic Plaques

BackgroundChronic hyperglycemia in diabetics patients can lead to a variety of macrovascular complications,including cardiovascular disease,cerebrovascular disease and peripheral vascular disease.Macrovascular complications are characterized by rich lipid and inflammatory deposits in the subintimal space with gradual plaque formation.The enlargement and sudden rupture of plaque can cause blood flow restriction,vascular occlusion,ischemia and necrosis of tissues and organs.The pathological basis of carotid plaque（CP）is atherosclerosis（AS）.The formation and development of carotid atherosclerotic plaques has been associated with cerebrovascular accidents.The current development of AS is thought to be a result of the co-dominance of pro-and anti-inflammatory mediators.Platelet to lymphocyte ratio（PLR）,neutrophil to lymphocyte ratio（NLR）are new inflammatory indicators.This article explored the association of PLR,NLR and complicated by CP in patients with type 2 diabetes mellitus（T2DM）.Hoping to help doctors to identify T2 DM patients at greater risk of cardiovascular and cerebrovascular events earlier in the clinic.It is also hoped that patients with expected negative outcomes will be more closely monitored and given relevant antiatherogenic therapy.ObjectiveTo analyse the correlation between PLR,NLR and complicated by carotid plaque status in patients with T2 DM.To analyse the reference value of PLR and NLR levels for predicting whether T2 DM patients complicated by carotid plaque or not.MethodThe clinical data of 369 patients with T2 DM hospitalized in the Department of Endocrinology of the Third Affiliated Hospital of Xinxiang Medical College from September 2019 to November 2021 were collected and statistically analyzed.Patients with T2 DM were classified according to whether or not they had complicated by CP: the T2DM-CP group,T2 DM + CP group.Observe the differences in general condition,blood indicators,PLR and NLR between the two groups.Patients with T2 DM were classified according to the number of complicated by CP: group 0（no plaque group）,group 1（1plaque group）,group 2（2 plaques group）,group 3（3 or more plaques group）.The four groups were observed for differences in general condition,blood parameters,PLR and NLR.Patients with T2 DM were divided into group P1,group P2,group P3 and group P4,based on PLR quartiles.To observe the difference in the incidence of CP among the four groups.Patients with T2 DM were divided into group N1,group N2,group N3 and group N4,based on NLR quartiles.To observe the difference in the incidence of CP among the four groups.Logistic regression analysis was used to evaluate the risk factors of T2 DM complicated by CP.ROC curves were used to assess the predictive efficacy of PLR and NLR on T2 DM patients complicated by CP.Result1.Both the PLR and NLR levels were higher in the group T2DM+CP compared to the group T2DM-CP（P<0.05）.2.The number of CP gradually increased with age,diabetes duration,hypertension incidence,NC,FIB,PLR,and PLR（all P <0.05）.The number of CP gradually increased with the decreasing level of TG（P <0.05）.3.With the increasing levels of PLR and NLR,the CP detection rate gradually increased（P<0.05）.4.Multi-factor logistic regression analysis: PLR（OR=1.02,P<0.05）,NLR（OR=2.12,P<0.05）,hypertension（OR=2.89,P<0.05）,and age（OR=1.09,P<0.05）were the independent risk factors for T2 DM patients.5.The ROC curve suggested that the best cut point for PLR to predict T2 DM patients complicated by CP was 119.95,AUC was 0.680,sensitivity was 54.7% and specificity was76.3%;the best cut point for NLR to T2 DM patients complicated by CP was 1.97,AUC was 0.698,sensitivity was 56.5% and specificity was 79.6%.ConclusionPLR and NLR were associated with complicated by carotid plaque in T2 DM patients.PLR and NLR levels had some reference value for predicting whether T2 DM patients had complicated by carotid plaque.