| Objective:To investigate the correlation between the levels of inflammatory markers NLR and PLR and type 2 Diabetes Atherosclerosis of carotid artery by analyzing the ratio of neutrophil to lymphocyte ratio（NLR）and platelet to lymphocyte ratio（PLR）in type 2diabetes mellitus with carotid atherosclerosis and type 2 diabetes.Methods:Retrospective study;A total of 306 hospitalized patients diagnosed as type 2diabetes in Department of Endocrinology from the First Affiliated Hospital of Dali University from January 2019 to July 2020 were collected.Among them,153 patients with carotid atherosclerosis（T2DM combined with CAS group）were selected as case group and 153 patients with simple type 2 diabetes group as control group（simple T2 DM group）.The general clinical data and relevant laboratory indexes of the subjects were collected.Through spss28 0 statistical analysis of the collected data.Results:（1）The age,duration,systolic blood pressure,pulse pressure,low density lipoprotein level,high-density lipoprotein level,fasting insulin level,NLR level and PLR level in patients with type 2 diabetes mellitus and group CAS were all higher than those in group 2,but the levels of glycerol three lipid,hemoglobin,and lymphoblast were lower than those in type 2 diabetes mellitus alone（P<0.05）.（2）The population was divided into three groups according to the NLR level.The incidence of CAS from group Q1 to group Q3 was 38%,50% and 62% respectively.There was significant difference among the three groups（P < 0.05）.According to the PLR level,the included population was divided into three groups.The incidence of CAS from group Q1 to group Q3 was 37.3%,51% and 61.8% respectively.There was significant difference among the three groups（P < 0.05）.（3）In all T2 DM patients,taking the occurrence of carotid atherosclerosis as the dependent variable,the results of binary logistic regression analysis showed that NLR（or = 1.545,95% CI: 1.062 ～ 2.248,P < 0.05）,PLR（or = 1.01,95% CI: 1.001 ～ 1.02,P< 0.05）,LDL（or = 1.317,95% CI: 1.005 ～ 1.727,P < 0.05）,age（or = 1.094,95% CI:1.057 ～ 1.133,P < 0.001）were still independent risk factors for CAS.（4）ROC curve was used to evaluate the clinical value of NLR and PLR in the diagnosis of carotid atherosclerosis in type 2 diabetes.Taking cut-off with the largest yoden index as the critical point,the optimal critical values of NLR and PLR are 1.785 and 88.26 respectively,and the area under the curve（AUC）are 0.623 [95% CI（0.560 ～0.685）] and 0.613 [95% CI（0.551～0.676）] respectively.NLR predicted that the sensitivity of carotid artery atherosclerosis in type 2 diabetes was 60.1% and specificity was 40.5%.The sensitivity and the specificity of PLR were 75.2% and 56.9%,respectively,in predicting the optimal cut-off value of carotid atherosclerosis in type 2diabetes.（5）The proportion of diabetic microangiopathy（diabetic retinopathy and diabetic nephropathy）in type 2 diabetic patients with carotid atherosclerosis group was higher than that in simple diabetes group（P < 0.05）,the difference was statistically significant.There was no statistically significant difference between the two groups in the prevalence of diabetic peripheral neuropathy（P > 0.05）.Conclusions:1.NLR,PLR,age and low density lipoprotein cholesterol are independent risk factors for carotid atherosclerosis in type 2 diabetes.2.NLR and PLR have certain predictive value for carotid atherosclerosis in type 2diabetes,which can help clinicians screen early diabetes patients with carotid atherosclerosis. |
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