Analysis Of Surgical Treatment Effect And Influencing Factors Of T3 Glottic Laryngeal Squamous Cell Carcinoma

Objective:To investigate the clinical efficacy and prognostic factors of total or partial laryngectomy in T3 glottic laryngeal squamous cell carcinoma.Methods:The clinical data of 84 patients with T3 glottic squamous cell carcinoma of the larynx were retrospectively analyzed,including gender,age,smoking,alcohol consumption,N grade,clinical stage,pathological grade,surgical method,surgical margin,postoperative radiotherapy,throat recurrence,cervical lymph node recurrence,and the correlation with the prognosis of laryngeal cancer.Kaplan-meier method was used for survival analysis,log-rank test or 2 test was used for univariate analysis,and Cox proportional risk regression model was used for multivariate analysis.Results:（1）The 5-year overall survival rate of T3 glottic laryngeal carcinoma was 75.0%,and the 10-year overall survival rate was 64.7%.The 5-year survival rate of partial laryngectomy was 79.6%,and that of total laryngectomy was 68.6%;（2）Univariate analysis showed that age,N grade,clinical stage,pathological grade,surgical margin,laryngeal recurrence and cervical lymph node recurrence were the related risk factors influencing the prognosis of laryngeal cancer（P<0.05）;（3）Multivariate analysis showed that age,N grade,surgical margin and recurrence were independent risk factors affecting the prognosis of laryngeal cancer（P<0.05）.Conclusion:（1）For selected T3 glottic laryngeal cancer patients,partial laryngectomy can achieve good tumor effect while preserving laryngeal function;（2）Age,N grade,clinical stage,pathological grade,surgical margin,laryngeal recurrence,cervical lymph node recurrence were the related risk factors influencing the prognosis of laryngeal cancer;（3）Age,N grade,surgical margin and recurrence were independent risk factors for prognosis of laryngeal cancer;（4）Individual standardized treatment was carried out for patients with intermediate and advanced laryngeal cancer.By accurately evaluating the scope of tumor invasion,safe incision margin was ensured,neck dissection was rationally selected,postoperative radiotherapy was timely or concurrent radiotherapy and chemotherapy were performed to improve the survival rate and quality of life of patients.