Efficacy Evaluation Of Vitamin A Preparations In The Treatment Of Recurrent Wheezing In Infants And Young Children

ObjectiveTo analyze the relationship between serum vitamin A level and repeated wheezing in infants and young children,and the effect of vitamin A intervention on the incidence frequency,clinical symptoms and pulmonary signs of wheezing.MethodsA total of 180 infants and young children aged 0-3 who were admitted to a large tertiary hospital for repeated wheezing from May 2020 to November 2021 were selected as the recurrent wheezing group（Inclusion criteria: 3-4 episodes of wheezing at the time of admission,wheezing during physical examination,audible wheezing and wheezing on lung auscultation,all of them were spontaneously conceived term delivery;exclusion criteria: nearly 3 Infants and young children who have taken vitamin A preparations for the first time and develop wheezing for the first time,children with wheezing caused by bronchial asthma,foreign body,bronchiolitis obliterans,heart disease,mediastinal tumor and congenital respiratory system diseases,etc.Children with disease history and family history,children who have used glucocorticoids and other immunomodulators within 1 month before enrollment,are likely to be lost to follow-up.）,And 160 healthy infants and young children matched with the observation group in terms of age,gender and admission time were collected as the healthy group（Healthy infants and young children born at full term with natural conception,previous health,no symptoms,underlying diseases and family history,no history of acute or chronic infection within 1 month before enrollment,no glucocorticoid use within 1 month before enrollment hormones and other immunomodulators.）,Liquid tandem mass spectrometry（LC-MS/MS）was used to measure the serum vitamin A levels of all subjects,and the differences in serum vitamin A levels between the infants with repeated wheezing and the healthy group were compared.The children were divided into two groups,the control group was only given basic treatment such as anti-inflammatory and antiasthmatic,the VA intervention group was given vitamin A preparation intervention treatment on the basis of basic treatment,and the serum vitamin A level was monitored monthly,and the serum vitamin A level reached normal.Afterwards,preventive dose supplementation was given,and the frequency of wheezing attacks,pulmonary signs and clinical symptoms of the two groups of children were followed up at 3,6,and 12 months;the frequency of wheezing attacks,pulmonary signs and clinical symptoms were compared between children with normal vitamin A and those with deficiency difference.Results1.The serum vitamin A level of the children in the repeated wheezing group was significantly lower than that in the healthy group,and the difference was statistically significant（0.26±0.14mg/L vs 0.34±0.14mg/L,P<0.05）.2.During the 1-year follow-up period,the VA levels,wheezing times,average hospital stay,and pulmonary wheezing disappearance time were significantly different in the VA intervention group at 3,6,and 12 months,and the differences were statistically significant（P<0.05）,there was no significant difference in the time of cough basically disappearing（P>0.05）.In the control group,the VA levels,wheezing times,average hospitalization days,and lung There was no significant difference in the disappearance time of wheezing in the upper part of the group（P>0.05）.3.Comparison of VA levels,wheezing times,average hospital stay,time to disappearance of pulmonary wheezing and time to disappearance of cough in VA intervention group and control group at 3,6,and 12 months of follow-up（（?）±s）Follow-up for 3 months There were no significant differences in the frequency of wheezing,the average hospital stay,the disappearance time of pulmonary wheezing,and the disappearance time of cough between the VA intervention group and the control group（P>0.05）.Compared with the control group,the number of wheezing was different,and the difference was statistically significant（P<0.05）,but there was no statistical difference in the average hospitalization days,the disappearance time of pulmonary wheezing and the time when cough basically disappeared（P>0.05）.;When the follow-up was up to 12 months,there were differences in the number of wheezing,the average hospital stay,and the disappearance time of pulmonary wheezing,and the difference was statistically significant（P<0.05）,but there was no statistical difference in the time when cough basically disappeared（P>0.05）.Conclusion1.Serum vitamin A deficiency was more common and severe in the recurrent wheezing group than in the healthy group.2.In children with recurrent wheezing and vitamin A deficiency,the number of wheezing episodes,the average length of hospital stay,and the time to disappearance of pulmonary wheezing were improved after serum vitamin A levels were corrected.