Study On Distribution Of TCM Syndromes And Risk Factors In Patients With Thyroid Nodules And Anxiety

ObjectiveThis study observed and analyzed the patients’ four-diagnosis information of TCM to determine the distribution characteristics of TCM syndrome types.Also,Analysis of demographic characteristics such as age,sex,history of alcohol and tobacco,urine iodine and BMI,etc.To discuss the related risk factors affecting nodular nature and anxiety degree,and explore clinical reference for TCM intervention of thyroid nodules with anxiety.MethodsThyroid nodules patients were selected as the subjects from June 2020 to January2021.According to the inclusion,exclusion and elimination criteria,General information and TCM syndrome questionnaire and self-rating anxiety scale(SAS)questionnaire was carried out,and relevant data(including demographic characteristics,related indicators and TCM symptoms)were collected.Then collated the data and carry out statistical analysis.Results(1)The distribution of general data:The proportion of male and female was1:6.09,and the duration of the disease within one year was accounting for 65.10%.The BMI and urine iodine in the normal range were accounting for 64.43% and 51.68%respectively.The proportion of nodule grade 3 was accounting for 57.05%.And the proportion of mild anxiety was accounting for 47.65%.(2)The distribution of TCM syndrome type: phlegm and blood stasis syndrome(31.54%)> Qi stagnation and phlegm obstruction syndrome(28.19%)> liver fire exuberant syndrome(26.85%)> heart-liver yin deficiency syndrome(13.42%).(3)The relationship between TCM syndrome types and general data: there was no difference in sex,age,duration of the disease,TI-RADS grade and anxiety degree(p>0.05).There were differences in BMI and urine iodine(p<0.05),Qi stagnation and phlegm obstruction syndrome and phlegm knot blood stasis syndrome were both different from liver fire exuberant syndrome and heart and liver yin deficiency syndrome in BMI(p<0.05).Qi stagnation and phlegm obstruction syndrome and liver fire exuberant syndrome had difference in urine iodine(p<0.05).(4)The relationship between nodule nature and anxiety degree and related factors:there was no correlation between nodule nature and age,sex,urine iodine,education,marital status,etc(p>0.05),but had correlation with BMI and history of alcohol and tobacco(p<0.05).There was no correlation between anxiety degree and age,sex,education level,BMI,urine iodine(p>0.05).But had correlation with age,marital status,history of alcohol and tobacco(p<0.05).Conclusion(1)The most common syndromes are phlegm and blood stasis syndrome,followed by Qi stagnation and phlegm obstruction syndrome,liver-fire exuberant syndrome and heart-liver yin deficiency syndrome respectively.(2)There was no difference between different TCM syndromes and sex,age,duration of disease and TI-RADS grade,but with differences in BMI and urine iodine.Both Qi stagnation and phlegm obstruction syndrome and phlegm and blood stasis syndrome in BMI were significantly higher than heart-liver yin deficiency syndrome and liver fire exuberant syndrome,and liver fire exuberant syndrome in urine iodine was significantly higher than qi stagnation and phlegm obstruction syndrome.(3)Thyroid nodules with anxiety patients who were younger,or with higher BMI,or had the history of alcohol and tobacco,will deserve the higher risk of nodule malignancy.Also,The younger,or unmarried,or married,or with history of alcohol and tobacco patients,will deserve the higher degree of anxiety.