Clinical Observation Of Jiawei Sangbaipi Decoction In Treating Acute Exacerbation Of Chronic Obstractive Pulmonary Disease With The Syndrome Of Phlegm-heat Obstructing Lung

Objective:Through the observation of the clinical effect of Jiawei Sangbai decoction in the treatment of AECOPD patients with phlegm-heat stagnation s-yndrome,explore the Jiawei Sangbai decoction’s Effectiveness and safety in cl-inical.Methods:The 74 enrolled cases after meeting the inclusion and exclusion criteria were randomly divided into treatment group and control group accordi-ng to 1:1.The control group was treated with Jiawei Sangbaipi Decoction bas-ed on conventional Western medical treatment（oxygen inhalation,anticonvulsa-nt and antiasthmatic,expectorant,Anti-infective）.The treatment course in both groups was 10 days.After treatment,changes in TCM syndrome scores,arteri-al blood gas analysis,lung function,serum inflammation indicators and BODE scores,and all receipts collected were statistically analyzed with SPSS 22.0.Results:（1）Comparison of general and baseline data between the two pretreatment groups:No statistical differences in data such as gender,age,medical conditi-on,smoking history,number of smokers,TCM syndrome score,BODE score,blood gas analysis,etc.They can be compared（P>0.05）.（2）Comparison of Syndrome Efficacy Between Two Groups:After treat-ment,the overall efficacy rate of the control group was 85.71%and the overa-ll efficacy rate of the treatment group was 97.1%.The difference was signific-ant（P<0.01）.The therapeutic effect of the treatment group was superior to that of the control group;both were significantly improved previously（P<0.05）,b-ut asthma,cough,sputum volume,sputum characteristics,lung lare,and stool c-haracteristics.Was better than the control group（P<0.05）,and the two groups were better than the control group（P<0.05）.There was no significant differe-nce in lip fever,thirst,and improvement in cyanosis.Nail（P>0.05）（3）Comparison of blood gas test indicators between the two groups:Intr-agroup comparison:Hypoxia and CO₂ retention in the two groups were signify-cantly improved and significantly different after treatment（P<0.01）;compariso-n between groups:The treatment group increased the degree P_aO₂ percentage was significantly higher than the control group（P<0.05）,but there was no sig-nificant difference between the two groups in improving carbon dioxide retenti-on（P>0.05）).This shows that Jiawei Sangbaipi decoction has more benefits i-n improving hypoxia.（4）Comparison of serum inflammation index between the two groups:Th-e inflammation index of the two groups decreased significantly on the 4th and10th days after treatment,and the difference was significant（P<0.01）.At 4 d-ays post-treatment,the treatment group was superior to the control group in l-owering WBC,N%,and CRP levels（P<0.05）;at 10 days post-treatment,the t-reatment group was significantly better than the control group.There was no s-tatistical difference in the decrease in CRP and N%values（P<0.05）and the decrease in WBC and ESR values compared to the control group（P>0.05）.T-his shows that the decoction of Sanbaipi can control inflammation more quickl-y and effectively.（5）Comparison of lung function between the two groups:After treatment,FEV₁%and FVC levels in the two groups improved significantly（P<0.05）,b-ut there was no significant difference in therapeutic effect between the two gr-oups.（P>0.05）.（6）Comparison of BODE scores between the two groups:Intragroup com-parison:FEV₁%,m MRC,and 6MWT scores were significantly reduced in the t-wo groups after treatment（P<0.01）,but there was no significant change in B-MI.（P>0.05）.Comparison between groups:After treatment,the treatment group was superior to the control group in improving m MRC and 6MWT（P<0.05）,but there was no significant difference in BMI and FEV₁%pred improvement between the two groups.It was（P>0.05）.This indicates that the treatment gr-oup has clear advantages over the control group in improving dyspnea and im-proving endurance of activity.Conclusion:Compared to the control group,Jiawei Sangbaipi decoction h-as obvious advantages in improving cough,wheezing,sputum volume,sputum quality,stool characteristics,lung wheezing,etc.You can see that it can be gr-eatly improved.Compared to simple Western medical treatment,Jiawei Sangbai-pi Decoction significantly increases P_aO₂ to improve hypoxia,reduces m MRC,6MWT scores,improves physical activity tolerance,improves dyspnea,It can s-ignificantly reduce CRP,WBC,N%and other serum inflammation.Jiawei Sa-ngbaipi decoction proves to be clinically usable with no clear therapeutic effect,excellent safety,no obvious side effects.