Clinical Observation On The Treatment Of Senile Stable Chronic Obstructive Pu Imonary Disease(Deficiency Of Both Lung And Kidney)with Modified Jinshui Liujun Decoction

Objective:To observe the clinical efficacy and safety of modified Jinshui Liujun Decoction in the treatment of elderly patients withstable chronic obstructive pulmonary disease(lung and kidney deficiency).Methods:Patients from geriatric and respiratory outpatient clinics of the Hospital of CDUTCM with a diagnosis of stable COPD(both lung and kidney deficiency)were randomly divided into 33 cases in the treatment group and 33 cases in the control group by SPSS22.0 random number generator.The control group used traditional Western medicine and the control group added Jinshui Liujun decoction pellets without decoction.Fifty-six days of treatment were used in both groups,and relevant data were counted before,28 days,and after treatment,respectively,and a one-year follow-up period was arranged to record the number of hospitalizations for acute exacerbations.Changes in BMI,6MWD,CAT score,number of hospitalizations due to acute exacerbations in one year,single points,and total TCM points were observed before and after treatment in both groups in order to evaluate the clinical effect of treatment with the Jinshui Liujun decoctions.Vital symptoms were also monitored,three major routines,liver function,renal function,electrolytes,18-lead ECG and adverse reaction table were recorded to evaluate the safety of this trial.Results:In this study,1 case was excluded because of not taking medicine according to the frequency and stopping medicine for 2 days,1 case dropped out because of automatic withdrawal and 1 case fell out because of not completing the whole experiment due to personal reasons.A total of 32 cases in the treatment group and 31 cases in the control group were included;(1)Overall effective rate:the overall effective rate of the control group was 77.42%in the treatment group and 87.5%in the treatment group,which was significantly better than that of the control group(P<0.01).(2)Single symptom and total score of TCM syndrome:the treatment group was better than the control group in improving shortness of breath and fatigue(P<0.05),and was significantly better than the control group in improving cough,wheezing,tinnitus,and soreness of waist and knee(P<0.01).The total score of TCM syndrome was improved in both groups after treatment,and the treatment group was better than the control group(P<0.01).(3)BMI:there was no significant difference between the treatment group and the control group(P>0.05).(4)Cat score:the cat score of the treatment group was better than that of the control group(P<0.05).(5)6-minute walking test:the 6-minute walking test in the treatment group was significantly better than that in the control group(P<0.01).(6)Acute aggravation times in one year:the number of acute aggravation in treatment group is better than that of control group(P<0.05).Conclusion:The addition and subtraction of Jinshui Liujun decoction is safe in the treatment of chronic obstructive pulmonary disease in the stable elderly(evidence of pulmonary and renal impairment),thereby improving clinical symptoms,enhancing exercise endurance and improving the quality of survival of patients.