| Objective: studies in abroad have found that the prevalence of non-alcoholic fatty liver disease(NAFLD)in obesity undergoing bariatric surgery is higher,and the risk factors of NAFLD vary greatly between different studies.At present,there is still a lack of research on the prevalence and risk factors of NAFLD based on liver biopsy in obesity undergoing bariatric surgery in China.We aimed to determine the prevalence and the predictors of NAFLD in a cohort of China with obesity undergoing bariatric surgery.Methods: From August 2019 to December 2020,184 consecutive patients requiring bariatric surgery underwent a liver biopsy in the First Affiliated Hospital of Jinan University.According to the SAF scoring system,the patient’s NAFLD and NASH prevalence were diagnosed.Assessing patient demographic data,anthropometric results,laboratory tests,obesity comorbidities and the correlation between NAFLD and NASH(Nonalcoholic steatohepatitis,NASH).Results: 164 cases were finally included in this study.Among them,101 cases were women(61.6%)and 53 cases(32.3%)were men.The average age is 29.5(±8.2)years,and the age range is 14-60 years.The average BMI was 39.4(±7.7)kg/m2,and the range of BMI was 27.8-73.5 kg/m2.Among the 164 obese patients,151 cases(92.1%)were NAFLD.13(7.9%)patients had steatosis <5%.NASH was 77 cases(51%).5cases with fibrosis stage ≥ F2,and one case with F4(0.6%).High-level ALT is an independent risk factor for predicting NAFLD.AST and body fat mass(%)are independent risk factors for predicting NASH.There were no intraoperative or postoperative complications related to the liver biopsy.Conclusions: Our research found that the prevalence of NAFLD,NASH and fibrosis among obese patients undergoing bariatric surgery is higher.In clinical practice,attention should be paid to the levels of ALT,AST,and body fat mass in these populations.When abnormal increases are found,the possibility of NAFLD should be considered.Intraoperative liver biopsy is safe and practical for diagnosing NAFLD. |
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