Prevalence And Risk Factors Of Erectile Dysfunction In Patients With Coronary Heart Disease

BackgroundCoronary heart disease(CHD)is one of the diseases with an increasing incidence rate in China in recent years.It is also a common and multiple diseases among men,especially in the elderly.Erectile dysfunction(ED)is also a common and multiple diseases in Chinese men,especially in middle-aged and elderly men.The prevalence of ED is about 40-70%in the Chinese male population,and its incidence rate is directly proportional to the increase of age.Moreover,the cognition that patients with coronary heart disease(CHD)are prone to erectile dysfunction(ED)has long been widely accepted.Recent studies have further found that the reason why patients with coronary heart disease(CHD)are prone to erectile dysfunction(ED)is that they may have similar risk factors.Moreover,the penile cavernous artery is significantly thinner than the coronary artery,which is more vulnerable to risk factors,so that patients with coronary heart disease(CHD)are more likely to have erectile dysfunction(ED)earlier.However,the actual clinical situation in China is that among patients with coronary heart disease(CHD)who go to the cardiovascular department,they are rarely asked whether there is erectile dysfunction(ED),resulting in insufficient research on the correlation between patients with coronary heart disease(CHD)and patients with erectile dysfunction(ED)There is a relative lack of data on the prevalence of erectile dysfunction(ED)in patients with coronary heart disease.ObjectiveTo study the prevalence of erectile dysfunction(ED)in patients with coronary heart disease(CHD),analyze the risk factors of erectile dysfunction(ED)in patients with coronary heart disease(CHD),and explore the correlation between coronary heart disease(CHD)and erectile dysfunction(ED)and clinical management.Methods1.Record the basic personal information of patients treated in Xinxiang second people’s Hospital from January 2019 to September 2019,including name,home address,contact number,etc.and pay attention to confidentiality.Collect patient information including general information(age,height,weight,etc.),personal history(such as smoking,long-term heavy drinking,etc.),and past diseases history(such as hypertension,diabetes,hyperlipidemia,etc.).2.Using the international erectile function score-5(IIEF-5)as the standard to judge whether there is erectile dysfunction(ED),100 patients with coronary heart disease(CHD)diagnosed by cardiovascular medicine were investigated,and the prevalence of erectile dysfunction(ED)in patients with coronary heart disease was counted.At the same time,a control group was established,87 adult married men without coronary heart disease were selected to count the erectile dysfunction(ED)in this group Then,the changes of erectile function in patients with coronary heart disease exposed to different risk factors were analyzed,and several related risk factors that may increase the prevalence of erectile dysfunction(ED)were studied.3.Evaluate the degree of erectile dysfunction(ED)by using the IIEF-5questionnaire.After obtaining the data,calculate the body mass index(BMI)through various factors,including the patient’s age,height,and weight,obtain the monocyte count(m)through blood routine examination,and obtain total cholesterol(TC),triglyceride(TG)and high-density lipoprotein(HDL)through blood lipid examination,monocyte count(M)/high-density lipoprotein(HDL)ratio(MHR),etc.These data were recorded as continuous variable data,represented by mean±standard deviation(x±s),and the difference between groups was compared by t-test.Personal history,diseases history,ED degree,and other categorical variables were expressed using percentages(%)and compared using theχ~2 test.Multiple logistic regression analysis was used to calculate the odds ratio(OR)with a corresponding 95%confidence interval(CI)for identifying the risk factors of erectile dysfunction(ED).SPSS 19.0statistical software was used for all statistical computing in the present study.All p values are two-sided,and p<0.05 was defined as statistically significant.Results1.General data analysisThe subjects of the two groups(coronary heart disease group and control group,non-coronary heart disease group)were randomly enrolled.They all explained to the research objects that they voluntarily joined the group and participated in the survey.2.Prevalence of erectile dysfunction(ED)The total prevalence of erectile dysfunction(ED)was 85.0%in the coronary heart disease(CHD)group and 24.1%in the non-coronary heart disease group;3.Logistic Regression AnalysisLogistic regression analysis showed that the increased risk of coronary heart disease(CHD)on erectile dysfunction(ED)was 3.520(95%CI 1.193-7.821,p<0.001);In patients with coronary heart disease,the increased risk of age for erectile dysfunction(ED)was 1.289(95%CI 1.048-1.612,p<0.01);The increased risk of hypertension on erectile dysfunction(ED)was 2.624(95%CI 1.034-6.985,p<0.01);The increased risk of diabetes mellitus for erectile dysfunction(ED)was 3.631(95%CI 1.238-7.938,p<0.001).The increased risk of heavy drinking on erectile dysfunction(ED)was 5.649(95 CI%1.508-9.720,p<0.001);The increased risk of smoking on erectile dysfunction(ED)was 3.470(95 CI%1.036-7.837,p<0.001);The increased risk of body mass index(BMI)for erectile dysfunction(ED)was 1.490(95%CI 1.206-2.286,p<0.05);The increased risk of monocyte(m)factor on erectile dysfunction(ED)was 2.498(95%CI 1.039-5.761,p<0.05);The increased risk of triglyceride on erectile dysfunction(ED)was 1.548(95%CI 1.061-2.337,p<0.001);The increased risk of total cholesterol on erectile dysfunction(ED)was 1.180(95%CI 1.046-1.323,p<0.01);The increased risk of monocyte/high density lipoprotein(MHR)factor for erectile dysfunction(ED)was 5.803(95%CI 2.178-11.034,p<0.001);High density lipoprotein(HDL)can reduce the risk of erectile dysfunction(ED)by 47.7%.4.The relevant factorsAge,hypertension,diabetes,smoking,long-term heavy drinking,BMI,monocyte count,TG,TC,and HDL were all ED-related factors.HDL was a protective factor and other factors were risk factors.This study proposed a new index,monocyte count(M)/high-density lipoprotein(HDL)ratio(MHR),which was statistically significant.Conclusion1.Coronary heart disease(CHD)is an independent risk factor for erectile dysfunction;2.age,hypertension,diabetes,smoking,long-term heavy drinking,BMI,M,MHR,TG,TC and other factors are all related risk factors for patients with coronary heart disease combined with erectile dysfunction;3.HDL is a protective factor for patients with coronary heart disease complicated with erectile dysfunction.