Predictive Value Of Serum Coagulation Function Combined With Platelet Parameters In Preeclampsia

Objective:To study the correlation and predictive value of serum coagulation function indexes（prothrombin time,activated partial thromboplastin time,fibrinogen）and platelet parameters（mean platelet volume,platelet count）with preeclampsia and maternal and fetal complications.To assess and predict sensitive indicators related to preeclampsia and maternal and fetal complications.Methods:Pregnant women who met the inclusion criteria and regular prenatal examination and gave birth in the Affiliated Hospital of Yangzhou University from September 2017 to December 2021 were selected.A total of 139 cases were included in the preeclampsia group.This experimental group included 85 cases of preeclampsia（without serious clinical manifestations）and 54 cases of severe preeclampsia（with serious clinical manifestations）.In addition,we randomly selected 139 healthy pregnant women as the control group who regularly checked and gave birth in our hospital at the same time.We collected their related clinical data and analyzed retrospectively:（1）the differences of general clinical data,maternal and fetal complications and coagulation function index and platelet parameters between the preeclampsia group,the control group,the preeclampsia group and the severe preeclampsia group;（2）Pearson correlation analysis was used to find the correlation between coagulation function index and platelet parameters and maternal and neonatal complications and the severity of preeclampsia.（3）The value of serum coagulation function index and platelet parameters in predicting maternal and infant complications,preeclampsia and disease severity assessed by receiver operating characteristic（ROC）curve.Results:1.Serum FIB and MPV of preeclampsia pregnant women were significantly increased,while PT,APTT and PLT were significantly decreased,and the more severe the disease,the more obvious the changes,the differences were statistically significant（P<0.05）.2.Serum FIB and MPV were negatively correlated with the time of first blood pressure rise,the time of termination of pregnancy and neonatal birth weight,and positively correlated with maternal and neonatal complications and severity of preeclampsia,but PT,APTT and PLT were the opposite.3.Serum FIB,MPV,PT and PLT had certain predictive value for perinatal complications.Serum MPV had a certain diagnostic predictive value for preeclampsia,area under the curve was 0.905,sensitivity was 80.60%,specificity was 84.30%;FIB+MPV combined with preeclampsia,area under the curve was 0.941,the sensitivity was 87.10%,the specificity was 87.90%.Serum FIB had the highest predictive value for preeclampsia severity,area under the curve of 0.983,sensitivity was 96.10%,specificity was 90.60%;FIB+MPV combined with the severity of preeclampsia,area under the curve was 0.993,the sensitivity was 96.30%,the specificity was 97.60%.Conclusions:1.The hypercoagulable state of blood in preeclampsia patients is related to the severity of the disease.By monitoring the changes of serum PT,APTT,FIB,PLT and MPV,it is helpful to assess the progress of the disease.2.Serum PT,APTT,FIB,PLT and MPV are related to adverse maternal and infant pregnancy outcomes,and can predict the occurrence of perinatal complications to a certain extent,and can improve the incidence of perinatal complications to a certain extent by actively monitoring the changes of serum coagulation function index and platelet parameters.3.Coagulation function index and platelet parameters are correlated with preeclampsia,serum PT,FIB and MPV have certain predictive value for preeclampsia and disease severity,and FIB+MPV combined with preeclampsia has the best predictive value,it is of great significance to evaluate the disease progression and guide the treatment of preeclampsia patients.