The Correlation Study Of Coagulation In Preeclapsia

Objective:To compare the change of normal pregnancy、mild preeclampsia、severe preeclampsia before pregnant women delivery detection of thrombin time(TT)、activated partial thromboplastin time(APTT)、 prothrombin time(PT)、 fibrinogen(FIB)、 D-dimer(D-D)、 fibrin degradation products(FDP).Preliminary discussion on blood coagulation index in the diagnosis of preeclampsia clinical significance,and analysis the ethnic differences between the kazak and the Han nationality of blood coagulation function the coagulation index for ethnic differences in the kazak and han nationality in pregnant women coagulation index,to establishment of treatment or timely termination of pregnancy to provide decision-making basis.Methods: Randomly selected from October 2015-March 2016 delivery our hospital the kazak and the han nationality in pregnant women.Adopt to retrospective analysis and stratified sampling,The third trimester can be divided into normal pregnancy group,mild preeclampsia group,severe preeclampsia group.Extracting 93 examples of normal pregnancy,84 cases of preeclampsia slightly pregnant women and 82 examples preeclampsia heavily pregnant women,thrombin time(TT),part of the live clotting enzyme time(APTT),prothrombin time(PT)and fibrinogen(FIB)content,D-dimer(D-D)and fibrin degradation products(FDP)analysis of the results.To analysis the results of thrombin time(TT)、activated partial thromboplastin time(APTT)、prothrombin time(PT)、fibrinogen(FIB)、Ddimer(D-D)、 fibrin degradation products(FDP).Results:(1)、 Preeclampsia severe pregnant women TT under mild preeclampsia pregnant women and pregnant women with normal pregnancy,preeclampsia mild thrombin time below the normal pregnancy pregnant women in pregnant women,and statistically significant differences(p < 0.05).(2)Preeclampsia heavily pregnant women FIB is higher than mild preeclampsia pregnant women and pregnant women with normal pregnancy,preeclampsia mild fibrinogen levels higher than normal pregnancy pregnant women in pregnant women,the difference was statistically significant(p < 0.05).(3)、The results of PT、APTT、DD、FDP between the three groups were slight differences no statistical significance(p > 0.05),but the FDP 、 APTT 、 D-D of preeclampsia is higher than normal pregnancy pregnant women.(4)、 In normal pregnancy group,kazak nationality pregnancy pregnant women FIB and D-D is higher than that of han nationality pregnant women,the difference was statistically significant(p < 0.05).(5)、 Preeclampsia patients with placental abruption,stillbirth,fetal distress and fetal growth restriction,the incidence of neonatal asphyxia were higher than normal pregnant women,the difference was statistically significant(p < 0.05).Conclusion:(1)Preeclampsia pregnant women blood coagulation function has obvious characteristics of high coagulation and fibrinolytic hyperfunction.(2)Blood coagulation function in kazak and han nationality pregnant women have differences,that indicate blood coagulation function are ethnic differences.(3)Detecting blood clotting index is help to prevention and treatment of obstetric complications,and has important guiding value to evaluate the pregnant woman and the fetus health condition.(4)Along with the preeclampsia patients disease progression,the adverse pregnancy outcome incidence has increased significantly.