Analysis Of 12-Year Data Of Inpatients With Mental Disorders Caused By Alcohol In Psychiatric Hospital

Objective:（1）By comparing the number,proportion and annual change trend of hospitalized patients with alcohol-induced mental disorders in a psychiatric hospital in Shandong Province from 2008 to2019,we can understand the current situation and changes of alcohol-induced mental disorders in more than 10 years;By analyzing its demographic characteristics and disease diagnosis subtypes,we can infer the onset characteristics and high-risk groups of the disease;（2）By analyzing the characteristics of drinking behavior of inpatients with this disease from 2011 to 2019,to explore its impact on diagnostic subtypes,and to understand the comorbidity and risk factors of these patients with other mental disorders.Methods:Data was used by the method of retrospective case analysis.（1）4725 inpatients with alcohol-induced mental disorders from2008 to 2019 were cllected in this study.The constituent ratio of patients with alcohol-induced mental disorders in all inpatients in each year was calculated,and their general demographic characteristics and diagnostic subtypes of alcohol-induced mental disorders were analyzed;（2）Taking2740 inpatients with alcohol-related mental disorders discharged from2011 to 2019 as the research object,collect their drinking behavior characteristics such as initial drinking age,drinking years,fixed drinking mode years,daily drinking volume,drinking frequency and drinking types,and understand their comorbidity with schizophrenia,bipolar disorder,depression and other mental disorders.Results:The first study:（1）From 2008 to 2019,4725 inpatients with mental disorders caused by alcohol were treated in our hospital,accounting for 3.27%of all inpatients,and the constituent ratio increased year by year（P<0.001）.（2）Male accounted for 98.6%,female accounted for 1.4%,male:female=71.7:1（P<0.001）;The average age was（45.5±9.9）years,People over 40 and over 50 account for the highest proportion（63.3%）;Farmers were the most（41.9%）,followed by unemployed and freelance（29.1%）,and cadres/employees increased year by year（P<0.001）;Married people accounted for 85.7%at most,and unmarried（P=0.047）,divorced and remarried,widowed and others（P<0.001）increased;（3）Dependence syndrome was the most common,accounting for35.9%,followed by withdrawal state（14.3%）and psychotic disorder（12.0%）.Although the proportion of harmful use（P<0.001）,dependence syndrome（P<0.001）,withdrawal state（P<0.001）,withdrawal state with delirium（P<0.001）,withdrawal state with epilepsy（P=0.01）,psychotic disorder（P<0.001）,residual or delayed psychotic disorder（P=0.003）is small,it tends to increase year by year.The patients diagnosed with"dependence syndrome"and"withdrawal state"had statistical differences in the age of first drinking,the number of years of drinking,the number of years of fixed drinking mode,the amount of alcohol consumed per day,and the frequency of drinking（P<0.05）.The second study:（1）The characteristics of drinking behavior of inpatients with alcohol-induced mental disorders from 2011 to 2019 are as follows:the age of first drinking is（7-66）years old,with an average of（24.36±7.05）years old;The average drinking years was（22.61±9.78）years,and drinking for 20 years was the most common（26.2%）,followed by drinking for 30 years（21.8%）;The average daily alcohol consumption is（65.98±34.60）standard cups,and the daily alcohol consumption was the most common（54.6%）at（50,75）standard cups,which was significantly higher than the total number of cases in other intervals（P<0.001）;The average number of years of fixed drinking mode was（8.54±7.16）years,and the most was（10,20）years,accounting for 28.2%;Drinking more than 5 times a day（not by meal）was the most common,accounting for71.5%,which was significantly higher than the total number of cases with other drinking frequencies（P<0.001）;Most patients（93.3%）mainly drink baijiu.22%of them drank with meals,77.2%of them drank in the morning and 64.5%of them drank before going to bed;There was a negative correlation between the age of first drinking and the years of fixed drinking mode（r=-0.17,P<0.01）,a positive correlation with the years of drinking（r=0.58,P<0.01）,and a negative correlation between the age of first drinking（r=-0.09,P<0.01）and the years of fixed drinking mode（r=-0.01,P<0.01）;（2）The comorbidity rate of alcohol-induced mental disorders and other mental disorders was 14.0%,of which schizophrenia accounted for27.6%,bipolar disorder 25.8%,depression 24.5%and other mental disorders 22.1%.Female patients in comorbidity group（χ~2=8.283,P=0.008）,Han nationality（χ~2=10.606,P=0.003）,harmful use（χ~2=181.965,P<0.001）,no withdrawal（χ~2=51.553,P<0.001）,no withdrawal state with delirium（χ~2=22.750,P<0.001）,no psychotic disorder（χ~2=38.389,P<0.001）,drink with meal（χ~2=8.620,P=0.004）,no morning drink（χ~2=209.504,P<0.001）,no drinking before going to bed（χ~2=130.584,P<0.001）,number of combined physical diseases（χ~2=-18.275,P<0.001）.The number of hospitalizations was 2-4（χ~2=52.669,P<0.001）,length of stay（χ~2=-6.212,P<0.001）,which was significantly different from the non comorbid group.The results of binary logistic analysis showed that harmful use,multiple hospitalization and physical diseases were positively correlated with comorbidity;Withdrawal state,withdrawal state with delirium,psychotic disorder and morning drinking were negatively correlated with comorbidity.Conclusion:（1）In recent 10 years,the number and proportion of inpatients with mental disorders caused by alcohol in the research unit have increased year by year;（2）Male,middle-aged,married and farmers are the high-risk groups of the disease,and dependence syndrome is the most common clinical subtype;（3）Most of the patients began drinking in the young adults,and mostly drank Baijiu liquor as the main drinking behavior.（4）The comorbidity of alcohol-induced mental disorders and other mental disorders is more common.Focusing on the risk population and the people with bad drinking patterns in the community is helpful to the early intervention of the disease.