Study Of Hypertriglyceridaemia Waist Phenotype Associated With Cognitive Impairment In The Elderly

Objective: This study mainly investigated the correlation between hypertriglyceridaemia waist（HTGW）phenotype and cognitive impairment in the elderly population in community,aiming to provide a more convenient method for the early screening of cognitive dysfunction in the elderly population in community.Methods: A total of 1448 older adults（aged ≥60 years）residing in the Xinglongzhuang coal mine community in Jining were selected for questionnaire,laboratory and clinical examinations,cognitive function assessment using the Chinese version of the Mini-mental state examination（MMSE）and depression status assessment using the Geriatric depression scale（GDS-15）.The subjects were divided into the normal waist-normal triglycerides（NWNT）group 、 the enlarged waist-normal triglycerides（EWNT）/the normal waist-elevated triglycerides（NWET）group and the hypertriglyceridaemia waist（HTGW）group according to waist circumference size and triglyceride level.One-way ANOVA and chi-square test were used to compare the general information,prevalence of cognitive impairment,and scores of various domains of cognitive function in the three study groups,and logistic regression analysis was performed to investigate the relationship between HTGW and cognitive impairment.Results:1.Compared with the NWNT and EWNT/NWET groups,the HTGW group had higher body mass index,systolic blood pressure levels,uric acid levels,total cholesterol levels,Low-density lipoprotein cholesterol levels and fasting blood glucose levels,and the HTGW group had lower High-density lipoprotein cholesterol levels（all P < 0.05）.The prevalence of cognitive impairment and diabetes mellitus was higher in the HTGW group（all P<0.0167）.2.Total MMSE scores were lower in the HTGW group than in both the NWNT group and the EWNT/NWET group（all P<0.05）.In each cognitive domain,verbal ability,orientation,attention and numeracy scores were lower than the other two groups（all P<0.05）.3.In this study population,the incidence of cognitive impairment was higher in the HTGW group.Using the Normal waist normal triglycerides（NWNT）group and the enlarged waist-normal triglycerides（EWNT）/the normal waist-elevated triglycerides（NWET）group as a reference,respectively,after also controlling for confounding factors such as age,sex,level of education,Body mass index,history of smoking,history of alcohol consumption,history of hypertension,history of diabetes,history of stroke,history of coronary artery disease,use of lipid-lowering medications,depressive status,High-density lipoprotein cholesterol,Low-density lipoprotein cholesterol,HTGW was a independent risk factor for cognitive impairment（OR=3.07,95%CI:1.24～7.63;OR=3.08,95%CI: 1.83～5.18）.Conclusion: This study found that the prevalence of cognitive impairment was higher in community-dwelling older adults with a positive HTGW phenotype compared to those who did not have the HTGW phenotype.With the above findings,HTGW may be an independent risk factor for cognitive impairment in the elderly,which holds the promise of providing an easier screening modality for early identification of cognitive impairment in the community-based elderly population.Control of abdominal obesity and hypertriglyceridaemia is intended to further reduce the likelihood of cognitive impairment.