Analysis Of Medication Rules Of Professor Wang Songling In The Treatment Of Insomnia

Objective: Based on data mining technology,this study sorted out Professor Wang Songling’s medications in the treatment of insomnia,explored Professor Wang Songling’s medication rules and clinical features in the treatment of insomnia,and formed a new core plan.In order to pass on the experience of famous doctors,provide new methods for the study of Chinese medical records,and provide new ideas for the treatment of insomnia.Methods: We have collected information such as the first consultation prescriptions of insomnia patients treated by Professor Wang Songling in Henan Provincial Hospital from 2015 to 2020.With the help of SPSS statistical analysis software,Liquorice software,frequency statistical analysis,cluster analysis,Mutiscale backbone analysis and Hierarchical networks analysis and other methods,we have excavated medication information,and summarized Professor Wang Songling’s medication rules in the treatment of insomnia.Results:1.Frequency(times)and frequency analysis: Among the 970 prescriptions included in the study,there are 253 Chinese medicines,and the number of medicines with a frequency>300 times is 14.Traditional Chinese medicine with a frequency≥50 times has 60 flavors,it accounted for about 85.80% of all medicine frequency.2.Statistical analysis of drug efficacy,meridian return,four qi and five flavors:The efficacy classification of traditional Chinese medicines with a frequency of≥ 50 times are mainly tranquilizers,tonic drugs,phlegm and cough and asthma drugs,blood circulation and blood stasis drugs,heat-clearing drugs,qi-regulating drugs,and diuretics Damp medicine,the main meridian is the heart,liver,and spleen,the four qi are mainly cold,calm,and warm,and the five flavors are mainly sweet,pungent and light.3.Cluster analysis: Traditional Chinese medicines with a frequency of≥50 times formed 8 groups of meaningful clustering prescriptions,which can reflect the characteristics of TCM syndrome differentiation and the characteristics of prescriptions and prescriptions of Professor Wang Songling in the treatment of insomnia.The specific groups are as follows:(1)Pinellia,Atractylodes,Coix Seed,Eupatorium,Alisma orientalis,Lotus Leaf,Peach Seed,Mustard Seed,Gastrodia,Amber(2)Celadon stone,rhubarb,coptis,citrus aurantium,bamboo,orange,poria,dragon teeth(3)Cyperus rotundus,Cangzhu,Liu Shenqu,Chinese yam,Scrophulariaceae,magnet(4)Magnolia officinalis,Platycodon grandiflorum,Fritillaria,sea octopus,Evodia,Gallus gallus(5)Guizhi,Oyster,Codonopsis,Scutellaria,Licorice,Jujube(6)Astragalus,Angelica,Fushen,Polygala,Sour Date Seed,Shichangpu,Tangerine Peel,Chuanxiong,Bupleurum,White Peony,Morinda Officinalis,Cuscuta Seed(7)Gardenia,turmeric,donkey-hide gelatin,Ophiopogon japonicus,Rehmannia glutinosa,Moutan cortex,Albizia julibrissin,Shouwu vine(8)Prunella vulgaris,Pueraria lobata,pangolin,scorpion4.Liquorice analysis:(1)Core prescriptions: Fushen,Amber,Atractylodes macrocephala,Pinellia,Longtooth,Turmeric,Coptis,Ligusticum chuanxiong,Fructus Aurantii,Shichangpu,Jujube Seed,Qingshi,Coix Seed,White Peony,Chai Hu,Albizia Skin.(2)Addition and subtraction compatibility of the first layer of drugs:Alisma orientalis-Adenophora adenophorum-Lotus leaf-Mustard seeds-Peach kernels-Gastrodia,Cang Fu-Cangzhu-Liu Shenqu-Gardenia-Mudan Peel-RhubarbOrange Red-Zhuru-Rhizoma Dihuang Shouwu vine,Zhejiang Fritillary-Evodia-Sea cuttlebone,Codonopsis-Astragalus-Angelica-Guizhi-Licorice-Polygala.(3)Addition and subtraction compatibility of the second layer of drugs: PuerariaPangolin-Scorpion-Sanqi,ginger-Jujube-Magnolia-Scutellaria baicalensis Georgi,Ejiao-Ophiopogon-Boziren,Scrophulariaceae-Yam-Gorgon,Poria-Tangerine PeelWindproof,Morinda officinalis-Cuscuta,Magnet-Cicada slough,Plantago-Cork,Artificial bezoar-Dannanxing.(4)Addition and subtraction compatibility of the third layer of drugs: oyster-prunella-uncaria-stiff silkworm,aster-bellflower-shegan-mu butterfly,northern adenophora-medlar-chrysanthemum,ephedra-gypsum,Xinyicocklebur,Gallus gallus domesticus-melon.(5)The fourth layer of drug addition and subtraction compatibility: loquat leaf-mulberry bark-oldenlandia diffusa,Gansongsalvia-red peony root,light bamboo leaf-Tongcao,Yizhiren-dogwood,Ligustrum lucidum-Eclipta prostrata,Nutmeg-psoralen.Conclusion:1.Professor Wang Songling’s guiding ideology for the treatment of insomnia: the general pathogenesis of insomnia is yin and yang imbalance,the disease is in the heart,involving the liver,spleen and other organs,and the pathological factors include phlegm,fire,depression,blood stasis,and deficiency.The treatment mainly focuses on removing phlegm and turbidity.According to the different pathogenic factors,the methods of clearing heat,promoting qi,promoting blood circulation,invigorating deficiency,and soothing the nerves are applied according to the different pathogenic factors.2.The principles of Professor Wang Songling in the treatment of insomnia: the core principle is to dissolve phlegm and turbidity,the most important compatibility principle is to calm the heart and calm the nerves,and the most commonly used prescription compatibility principles are to resolve phlegm-clear heat-promote qi-soothe the nerves.3.Professor Wang Songling’s medication rules for the treatment of insomnia: the core prescriptions are Fushen,Amber,Atractylodes,Pinellia,Dragon’s Teeth,Turmeric,Coptis,Chuanxiong,Fructus Aurantii,Shichangpu,Sour Ziziphus,Qingshi,Coix,White Peony,Bupleurum,Albizia Bark.4.Based on the core prescription,the rule of addition and subtraction according to the symptoms: treatment based on pathological factors such as phlegm,fire,depression,blood stasis,and deficiency.To relieve turbidity,resolve phlegm and remove blood stasis,Alisma-adenophora-lotus leaf-mustard seed-peach kernel-gastrodia.Relieving Zhuyu,clearing phlegm heat,peace of mind,Cyperus rotundus-Cangzhu-Liu Shenqu-Gardenia-Moutan Bark-Rhubarb-Orange-ZhuruRehmannia glutinosa-Shouwu vine.To invigorate qi,nourish blood and soothe the nerves,Codonopsis-Astragalus-Angelica-Guizhi-Licorice-Polygala.Yuyin and clearing away heat,communicating heart and kidney,donkey-hide gelatinOphiopogon-Baiziren.To clear away heat and reduce dampness and stomach,ginger-jujube-magnolia officinalis-skullcap.To clear away heat and resolve phlegm,suppress soreness and relieve pain,harm the stomach and reduce Ni,Zhe FritillaryEvodia-Cutfish.Tongluo Quyu,promote clearing Yang,Pueraria lobata-pangolinscorpion-notoginseng.5.On the basis of the core prescription,the law of compatibility addition and subtraction: dizziness,the line of sight dim,upset and insomnia,oyster-prunellauncaria-stiff silkworm.Hot flashes,night sweats,irritability and insomnia,Adenophora sylvestris-wolfberry-chrysanthemum.Pain and diarrhea,Poria-tangerine peel-Fangfeng.With nocturnal emission,Scrophulariaceae-Yam-Gorgon.Deficiency of liver and kidney,Morinda officinalis-Cuscuta.Phlegm-heat obstruction,bad throat,aster-bellflower-shegan-wood butterfly.Lung heat,asthma and cough,loquat leaves-mulberry white bark-oldenlandia diffusa.Blood stasis in the heart,pain in the heart,Gansong-Danshen-Red peony root.Urinary dripping and astringent pain,Psyllium-Cork.Tinnitus,magnet-cicada slough.Annoyance and palpitations,artificial bezoar-Dannanxing.6.Commonly used medicine pairs: light bamboo leaves-Tongcao,YizhirenFructus corni,Ligustrum lucidum-Eclipta prostrata,Nutmeg-psoralen,Ephedragypsum,Xinyi-Xanthium,Gallus gallus domesticus-Gualou.7.Insomnia syndrome and treatment: syndrome of phlegm-heat disturbanceclearing phlegm and calming nerves;syndrome of disturbance of liver-fire-dispelling liver and heat;syndrome of deficiency of both qi and blood-invigorating qi and blood;syndrome of inadequacy of heart and kidney-yin and clearing heat.