Hu Ziyi’s Experience In Treating Insomnia And Analysis Of Medication Rule Based On Data Mining Methods

Objective: Through the method of data mining,the clinical experience of Hu Ziyi in treating insomnia was discussed to provide new ideas and methods for TCM treatment of insomnia.Methods: The cases of this study were derived from the outpatient cases of Director Hu Ziyi in Jiangxi Provincial Hospital of Traditional Chinese Medicine from January2021 to December 2022.The database of Hu Ziyi’s insomnia treatment was established by WPS Office.WPS Office was used to calculate the basic information of drugs and symptoms.SPSS Modeler18 and SPSS Statistics 22.0 software were used for association rule analysis,correlation analysis,cluster analysis and principal component factor analysis.Results:1.Results of medication rules:(1)Frequency analysis of traditional Chinese medicine: A total of 175 prescriptions were counted,176 kinds of different traditional Chinese medicine were used 2466 times.The top 10 most frequently used flavors were licorice(154 times,frequency 9.33%),sour jujube seed(120 times,frequency 7.27%),poria coia(117times,frequency 7.09%),bupleurum bupleurum(90 times,frequency 5.45%),Radix uchinensis(90 times,frequency 5.45%),Ligusticum Chuanxiong(75 times,Frequency: 4.55%),tangerine peel(72 times,4.36%),pinellia pinellia(70 times,4.24%),paeoniae alba(67 times,4.06%)and ginger(64 times,3.88%).The four Qi and five tastes are mainly warm,flat,sweet and Xin,which mainly belong to the four channels of the heart,spleen,liver and lung.(2)Correlation analysis: After analysis and classification,four types of combinations were obtained: the first type was "honeysuckle-shoot gan-Mabo-burdock seed";The second category is "stir-fry grain sprouts-stir-fry malt";The third type is "keel-oyster";The fourth type is "Eucommia-mulberry parasitism";The fifth type is the Epimedium.(3)Association rules: 26 order 24 drug association rules and 25 order 3 drug association rules were obtained.The drugs with strong correlation degree mainly came from Erchen Decoction and Suanzaoren Decoction.(4)Cluster analysis: the copolymerization was divided into 4 classes.The first class(C1)was oyster,keel,Turniflora,Acacia,Fu God,Bupleurum,white peony and floss wheat.The second group(C2): Ligusticum chuanxiong,Zhimu,Suanjujube seed,Radix aconitum;Category 3(C3): Angelica sinensis,Stir-fried Atractylodes sinensis;Class 4(C4): Radix polygonae,Rehmanniae rehmanniae,Schisandra chinensis,ginger,jujube,codonopsis codonopsis,Tangerine peel,pinellia aurantia,bamboo shaurus,poria cocos,licorice.(5)Principal component factor analysis: F1: Codonopsis,Fructus aurantii,Rehmanniae rehmannii,Schisandra schisandra and Radix polygonae;F2: Floating wheat,Fu God,Acacia flower;F3: Oyster,keel,Bupleurum,Turpentine,Angelica sinensis;F4: Bamboo Shavings,Pinellia pinellia and Tangerine peel;F5: jujube,ginger,poria cocos;F6: Zhimu,ligusticum chuanxiong,sour jujube seed,Radix aconitum;F7: Licorice,Paeony and Stir-fried Atractylodes atractylodes;There are seven common factors.2.Results of syndrome differentiation:(1)Symptom frequency analysis: Among the 175 cases in this study,66 common symptoms(frequency ≥5)of insomnia were treated by Mr.Hu Ziyi,among which 22 were symptoms with frequency ≥10%.(2)Tongue image and pulse: According to the statistics,11 kinds of tongue texture appeared 202 times in total,among which frequency ≥5% was light red tongue texture(77 times,frequency 38.12%),red tongue texture(69 times,34.16%),dark tongue texture(15 times,7.43%),tooth marks on the tongue edge(11 times,5.45%).A total of 10 species of moss appeared and 176 times appeared.Among them,the occurrence frequency ≥5% in turn is thin white(103 times,frequency 58.52%),thin yellow(35 times,frequency 19.89%),yellow greasy(14 times,frequency 7.95%),white greasy(9 times,frequency 5.11%);A total of 16 kinds of pulse appeared,and the cumulative frequency was 395 times.Among them,pulse string(137 times,frequency 34.68%),pulse fineness(108 times,frequency 27.34%),pulse sinking(58times,frequency 14.68%),inch pulse floating(26 times,frequency 6.58%),pulse slippage(24 times,frequency 6.08%)and pulse number(14 times,frequency 3.54%)occurred successively.(3)Distribution of syndrome types: Through analysis and induction,a total of19 syndrome types were obtained,and those with more than 10 cases were successively damp-heat disturbance of the heart,liver-qi stagnation syndrome,liver-blood deficiency syndrome,heart-kidney disjunction syndrome and heart-spleen deficiency syndrome.(4)Correlation analysis of symptoms: there were 37 association rules for second-order symptoms,among which "difficulty falling asleep" and "palpitation" had the highest confidence;There were 30 association rules of third-order symptoms,among which "dry mouth" and "bitter mouth and poor sleep" had the highest confidence.There were 3 association rules of 4 symptoms,among which "easy waking" and "poor sleep and dry mouth and difficulty in falling asleep" had the highest confidence.Conclusion:1.The disease of insomnia is in the heart,which is closely related to the liver,spleen and kidney.Ying Wei disharmony,Qi and blood deficiency,work and escape disorder,improper diet,physical deficiency for a long time,mood disorders and so on lead to the disorder of mind,or mind disturbed and insomnia,and phlegm turidity,blood stasis,mood disorder is an important cause of repeated insomnia.2.The treatment of insomnia should pay attention to replenishing qi and nourishing blood,calming the mind and fixing the will,and eliminating phlegm and blood stasis.In addition,patients should pay attention to mental adjustment,provide proper psychological counseling,try to avoid the stimulation of panic,excessive tension,excitement,anxiety and other adverse factors,and pay attention to strengthen exercise,regular diet,enhance the body immunity,and do physical labor according to your ability.