| Objective: To observe the clinical efficacy of Wenyang Tiaozhong Decoction in the treatment of slow transit constipation(STC)of Syndrome of Yang deficiency and coagulation cold through clinical research,and to further explore Professor Xi Zuowu’s clinical experience,prescription and medication Features and form academic thoughts;at the same time,it provides reference for the mechanism research and clinical promotion of Wenyang Tiaozhong Decoction in the treatment of slow transit constipation of Syndrome of Yang deficiency and coagulation cold.Method: The syndrome differentiation type of the anorectal outpatient and inpatient treatment at the Second Affiliated Hospital of Henan University of Traditional Chinese Medicine(Henan Provincial Hospital of Traditional Chinese Medicine)from December1,2019 to December 31,2020 was selected as Syndrome of Yang deficiency and coagulation cold.A total of 102 patients with STC were randomly divided into treatment group and control group 1:1 using IBM SPSS 26.0 software.Each group had 52 cases.After being enrolled,the treatment group was taken orally by the Chinese Pharmacy of Henan Provincial Hospital of Traditional Chinese Medicine.The decoction of traditional Chinese medicine decoction Wenyang Tiaozhong Decoction,the control group was orally taken the compound Polyethylene Glycol Electrolyte Powder(Ⅳ)uniformly provided by the Western Pharmacy of Henan Provincial Hospital of Traditional Chinese Medicine.The observer records in detail the quantitative scores of TCM syndromes,CSS,Colonic Transit Test,Bristol stool traits,SCBM,PAC-QOL,safety indicators,and adverse effects of the patient before treatment,2 weeks of treatment,4 weeks of treatment,and 4 weeks after drug withdrawal.Incident report form,compliance evaluation,complete the filling of case report form in a timely and accurate manner.The study data was analyzed using IBM SPSS 26.0 statistical software to evaluate the clinical efficacy and recurrence rate of the two groups of drugs in the treatment of TCM syndrome differentiation of Yang-deficiency-cold-coagulation STC.Make an objective evaluation of safety.Results: A total of 102 cases of STC patients with Syndrome of Yang deficiency and coagulation cold were included in the clinical efficacy observation.During the clinical observation period,there were no cases of drop-off and elimination in the two groups.(1)Comparison of baseline data: The gender,age(years),course of disease(years),efficacy indicators and safety indicators of the two groups before treatment were not statistically significant(P>0.05),and they were Comparability.(2)Comparison of TCM syndrome scores,effective rates and recurrence rates:There are significant differences in TCM syndrome scores between the groups at 2weeks,4 weeks,and return visits(P<0.01),and the treatment group is better than the control group;within the group In comparison,the results of each time node were statistically different from those before treatment(P<0.01).The difference between the treatment group after 4 weeks of treatment and the return visit was not statistically significant(P=0.302>0.05),and both groups of drugs can be improved Syndrome score,but the long-term efficacy of drugs in the treatment group is better than that of the control group;the effective rate of the treatment group for 4 weeks is statistically significant compared with that of the control group(P<0.01),and the treatment group(92.16%)is significantly better than the control group(78.43%);compared with the control group,the recurrence rate of the treatment group was statistically significant(P<0.05),and the treatment group(12.77%)was significantly better than the control group(20%).(3)Comparison of CSS scores and PAC-QOL scores: CSS scores are statistically significant between groups and within groups at various time nodes after medication(P<0.05).The improvement effect of the control group is better than that of the treatment group,but the CSS scores of the control group increase after drug withdrawal Obviously,it indicates that the long-term efficacy of the drug in the treatment group is better than that in the control group;the PAC-QOL score is not statistically different between the two weeks of treatment(P=0.147>0.05),and the PAC-QOL score is between and within the group during the rest of the treatment The difference was statistically significant(P<0.05),indicating that the two groups of drugs had an improvement effect on the PAC-QOL score after 2 weeks of treatment and there was no difference,but the long-term improvement of the score of the treatment group was better than that of the control group.(4)Comparison of Bristol stool traits,colonic transit test,and SCBM: There were statistically significant differences in Bristol stool traits between the two groups after treatment for 2 weeks,4 weeks of treatment,and at the time of return visit(P<0.05)The difference between colonic transit test before treatment and the return visit is statistically significant(P<0.01).The analysis of the data shows that the normal ratio of the transmission test in the treatment group(86.27%)is better than the control group(45.1%)during the return visit.The transmission improvement ability is much better than that of the control group;the comparison between the two groups of patients with SCBM treatment for 4 weeks is not statistically significant(P=0.169>0.05),and the difference between the node groups and within the group before and after treatment is statistically significant(P<0.05);it shows that the two groups of drugs can improve stool characteristics and intestinal transit,but the long-term efficacy of the drugs in the treatment group is better than the control group.(5)Both groups of patients underwent general physical and chemical examinations such as blood routine,liver and kidney function,physical examination,and anorectal examination before treatment,2 weeks of treatment,and 4 weeks of treatment.There was no abnormal examination after taking the medicine.For adverse reactions,the overall assessment is safe.Conclusion: Wenyang Tiaozhong Decoction can effectively improve stool characteristics and intestinal transit function when treating slow transit constipation of Yang-deficiency and cold-coagulation type.It has a definite effect on the defecation and accompanying symptom improvement of patients with constipation,and can improve the quality of life of patients.It has a low recurrence rate,and the curative effect of TCM symptoms is significantly better than that of compound polyethylene glycol electrolyte powder(Ⅳ).The patient can be well tolerated and has high safety,which is suitable for clinical application. |
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