Clinical Efficacy And Safety Of Nano-microneedle-assisted Phenylethyl Resorcinol For The Treatment Of Infraorbital Dark Circles

Objective: The objective of this study was to evaluate the efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles.Methods: Twenty female participants were randomized to two groups.In the experimental group(group E),participants received topical phenylethyl resorcinol gel under one side of the orbit once a day and topical plus nano-microneedle-assisted phenylethyl resorcinol gel under the other side twice a week.In the control group(group C),participants were treated with gel without phenylethyl resorcinol.Melanin index(MI)and erythema index(EI)were measured before the session(T0),4 weeks and 8 weeks during the treatment session(T4,T8),and 1 month and 2 months after the last session(T12,T16).The global assessment was performed by a blinded dermatologist,and participants were asked to score 0-10 points according to the degree of pain.Results: The mean value of MI in group E was significantly lower than the baseline at T8(P<0.05),and nano-microneedle side decreased more significantly than the other side(P<0.05).However,there was no difference of MI before and after treatment in group C(P>0.05).The satisfaction of the nano-microneedle side was higher than that of the other side(P<0.05)There was no big difference of the mean EI between the two sides(P>0.05).The treatment was well tolerated and no serious adverse effects were reported.Conclusion: Phenylethyl resorcinol combined with nano-microneedle could be an effective and safe method for infraorbital dark circles.