| Objective: The incidence of non-alcoholic fatty liver disease is increasing year by year throughout the world.At present,the incidence of NAFLD in my country has exceeded25%,but there is no unified diagnosis and treatment standard for NAFLD,and the pathogenesis of NAFLD is not fully understood.Liver biopsy cannot be accepted by most people,so there are still many difficulties in the prediction and detection of NAFLD.This article analyzes and detects the body composition of patients with non-alcoholic fatty liver disease(Nonalcoholic fatty liver disease,NAFLD),and explores the correlation between visceral fat area,waist-to-hip ratio and other body composition abnormalities with the occurrence and severity of NAFLD,provide a basis for the non-invasive diagnosis and follow-up treatment of NAFLD.Methods:A collection of patients diagnosed with fatty liver by liver ultrasound or CT in Shengjing hospital of affiliated to China Medical University from July 2019 to February2021.After strict inclusion and exclusion criteria,100 people were selected to meet the NAFLD diagnostic criteria and enrolled(59 males,41 females),between the ages of18-60,all have signed the informed consent form for study entry).All patients were tested for liver function,kidney function,blood lipids,fasting blood glucose,liver elasticity and hardness,and body composition analysis.Groups are divided into NAFLD mild group(CAP≤265d B/m,n=42)and NAFLD severe group(CAP>265d B/m,n=58)with the CAP value as the reference value of the degree of fatty liver degeneration,and compare the two groups of measurements the difference between the values,and logistic regression analysis of the risk factors of NAFLD onset and disease progression.Results: There was no significant difference in age and gender of NAFLD patients between mild and severe groups.In the severe group: Aspartate aminotransferase [42(30,74)],Cholinesterase [10734.5±1588.18],Fasting blood glucose [5.79(5.46,6.09)],Liver stiffness value [8.8(6.53,10.43)],Body mass index [29.645±4.07],Body fat rate [30.9(28.13,34.98)],Visceral fat area [106(94.75,123)] and Waist-to-hip ratio [0.90±0.056]are Significantly higher the mild group:aspartate aminotransferase [29.5(20,51)],Cholinesterase [9999.12±1784.824],Fasting blood glucose [5.36(5.02,5.83)],Liver stiffness value [6.95(6.13,8.35)],Body mass index [25.357 ± 2.35],Body fat rate[26.75(25.18,28.3)],Visceral fat area [94(83,99)],Waist-to-hip ratio [0.85±0.039](P<0.05).Using binary logistic multivariate regression analysis,the independent risk factors for NAFLD progression include Fasting blood glucose(OR=2.933,P=0.006,95%CI:1.353-6.355),Body mass index(OR=1.956,P=0.019,95%CI:1.114-3.435),Visceral fat area(OR=0.92,P=0.03,95%CI:0.854-0.992),Waist-to-hip ratio(OR=2.52E+15,P=0.013,95%CI: 2043.027-3.11E+27).Conclusion:Fasting blood glucose,Body mass index,Visceral fat area and Waist-to-hip ratio are all related to the severity of NAFLD and are independent risk factors for disease progression in NAFLD patients. |
PDF Full Text Request