Different Drugs In The Treatment Of High-risk Human Papilloma Vrius Persistent Infection And Cervical Precancerous Lesions Complicated With High-risk Human Papilloma Virus Infection

Objective: Compare the clinical effects of different drugs on high-risk HPV persistent infection and cervical precancerous lesions with high-risk HPV infection.Methods: From September 2018 to January 2020,120 patients with high-risk HPV persistent infection and cervical precancerous lesions complicated with high-risk HPV infection were randomly divided into 4 groups.Nr-CWS group(30 patients)was given Nr-CWS vagina once every other day for 10 times.Baofukang suppository group(30patients)was treated with Baofukang suppository and interferon group(30 patients)was treated with recombinant human interferon α-2b suppository for 3 months.The blank control group(30 patients)was not given any drugs or special treatment,only regular follow-up.All patients were examined by colposcopy and histopathology when necessary for HPV and TCT,at 1 month,4 months,8 months and 12 months after treatment.The negative conversion rate of HPV,TCT changes,colposcopy and histopathological changes were compared in each group.Results: One month after drug withdrawal,the negative conversion rate and total effective rate in the Nr-CWS group(56.67%/ 63.33%)were significantly higher than those in the Baofukang suppository group(23.34%/ 36.67%)and the blank control group(10.00%/ 30.00%)(P < 0.05).The negative conversion rate was higher than that in the interferon group(16.67%/43.34%).The difference was statistically significant(P < 0.05).But there was no significant difference in the total effective rate(P > 0.05).There was no significant difference in the negative conversion rate and total effective rate among the other three groups except Nr-CWS group(P > 0.05).Four months after drug withdrawal,the negative conversion rate in the Nr-CWS group(60.00%)was higher than that in the other three groups.Except for the Baofukang suppository group(36.67%),there was a significant difference in the negative conversion rate between the two groups(P < 0.05).The total effective rate of the Nr-CWS group(73.33%)was higher than that in the Baofukang suppository group(63.33%)and the interferon group(60.00%),but there was no significant difference compared with the blank control group(40.00%).The difference was statistically significant(P < 0.05).There was no significant difference in the negative conversion rate and total effective rate among the other three groups except Nr-CWS group(P > 0.05).Eight months after drug withdrawal,the negative conversion rate(73.33%)and total effective rate(83.33%)in the Nr-CWS group were higher than those in the Baofukang suppository group(50.0%/73.33%)and the interferon group(50.00%/73.33%),but there was no significant difference(P > 0.05).Compared with the blank control group(33.33% /46.67%),there was a significant difference between the two groups(P < 0.05).There was no significant difference in negative conversion rate and total effective rate between Baofukang suppository group and interferon group(P >0.05).The total effective rate of Baofukang suppository group and interferon group was higher than that in the blank control group,and the difference was statistically significant(P < 0.05).Twelve months after drug withdrawal,the negative conversion rate(73.33%)and total effective rate(80.00%)in Nr-CWS group were higher than those in Baofukang suppository group(53.33%,73.33%),interferon group(56.67%,76.67%)and blank control group(33.33%,46.67%),but the difference was not statistically significant(P >0.05).The results of comparison of negative conversion rate and total effective rate among groups were the same as those 8 months after drug withdrawal.There was no significant difference in the outcome of TCT,colposcopy and LSIL among the four groups after drug withdrawal.Conclusion: External use of Nr-CWS,Baofukang suppository and recombinant human interferon α-2b suppository have significant efficacy in the treatment of high-risk HPV infection,and can increase the negative conversion rate of HPV.External use of Nr-CWS is better than traditional Baofukang suppository and recombinant human interferon α-2b suppository to some extent.The safety and feasibility of the three drugs are all at a high level,which is worthy of clinical promotion and application.