| Objective:This study was performed to evaluate the rate and pattern of HRHPV infection clearance after successful conization for high-grade CIN and to analyze factors associated with such clearance. Methods:We analysed retrospectively109patients who were visiting in the Department of Gynecology of Nanjing Drum Tower Hospital from2010to2011.All patients who underwent loop electrosurgical excision procedures (LEEP) owing to HRHPV-associated high-grade CIN were included. All patients had negative resection margins on LEEP specimens and underwent HPV testing with the hybrid capture2system at3-,6-and9-month follow-up visits after LEEP. And studied to observe the postoperative situation of the rate of HRHPV persistent infection and clearance. Results:Persistent HPV infections were detected in35.8%,33.9%and29.4%of patients at3,6and9months after LEEP, respectively. HRHPV persistent infection and clearance rates did not differ by parity, glandular extension, severity of cervical lesion or chinese medicine syndrome type. However, The rates of persistent HPV infection were significantly higher in patients with HPV DNA loads>500RLU/PC before LEEP (p<0.05) and clearance rates were significantly slower in patients with HPV DNA loads>500RLU/PC before LEEP (p<0.05). Logistic linear regression analysis showed that persistent HPV infection was a risk factor for persistence of histological abnormalities after LEEP (P=0.022, OR=12.545,95%CI=1.451-108.486). Conclusion:HRHPV infections cleared gradually after the effective conization. HPV DNA loads>500RLU/PC before LEEP was a risk factor for persistent HPV infection and HRHPV clearance.It is important to accurately evaluate the rate and pattern of HRHPV infection clearance after LEEP and to analyze factors associated with persistent HPV infection for the prevention of residual disease and recurrence after conization. |
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