Prevalence And Clinical Characteristics Of Intestinal Bacterial Overgrowth In Infants With Chronic Diarrhea

Objective:Diarrhoea is a common disease in children and the second leading cause of death among children under 5 years old worldwide.Prolonged diarrhea can lead to malnutrition,growth and development disorders,and even death in children.Studies have shown that chronic diarrhea is closely related to the disorder of intestinal flora and is a vicious circle of cause and effect.SIBO is a manifestation of flora disorder,such as diarrhea,abdominal distension,abdominal pain,malabsorption and so on.There are few studies on SIBO in children at home and abroad.It is of great significance to study the occurrence of SIBO in infantile diarrhea and analyze its clinical characteristics.Methods: A retrospective cross-sectional study method was used to select 310 infants with chronic diarrhea,including 188 males and 122 females,average age of 0.73±0.56 years.The hydrogen breath test is used as a diagnostic method for SIBO.Calculate the positive rate of hydrogen breath test,and analyze the clinical characteristics of positive children.Results: 1、The positive rate of lactose hydrogen breath test was 13.87%(43).2、Comparison between the two groups,the incidence of dilute stool and blood stool in the positive group was higher than that in the negative group,and the difference was statistically significant(P<0.05).There was no significant difference in fecal frequency,abdominal distension,vomiting,crying and dehydration(P>0.05).The incidence of anemia 、 growth retardation and lactose intolerance in the positive group were significantly higher than those in the negative group,and the difference was statistically significant(P<0.05).3、After being fed with lactose-free milk powder and treated with probiotics,the symptoms of 40 cases(40/41)were relieved at discharge and 1 case(1/41)was not significantly relieved at discharge.Conclusion: 1、SIBO is more common in infants coupled with chronic diarrhea.2、Clinical manifestations may include diarrhea,abdominal distension,vomiting,increased crying and dehydration,but there is no significant specificity.It is prone to dilute stool,blood stool,anemia,and growth retardation.SIBO increases the risk of lactose malabsorption in children with diarrhea.3、SIBO of infants is effective in diet adjustment and probiotic treatment.