Meta-analysis Of The Safety And Effectiveness Of Docetaxel Combined With Carboplatin In The Treatment Of Ovarian Cancer

Objective To compare the safety and effectiveness of docetaxel combined with carboplatin and other chemotherapy drugs in the treatment of ovarian cancer via Meta-analysis,so as to illustrate the advantages of docetaxel combined with carboplatin in clinical application and provide a strong reference for clinicians to choose chemotherapy regiments.Methods 1.Randomized controlled trials comparing docetaxel combined with carboplatin and her chemotherapy agents in the treatment of ovarian cancer were collected by retrieving databases such as China National Knowledge Infrastructure(CNKI),VIP Database for Chinese Technical Periodicals(VIP),Wanfang Database,Pub Med,Cochrane Library,Embase,Web of Science.2.Retrieval Strategy:The retrieval strategy was first formulated after repeated retrieval based on the PICOS principle,and the retrieval was subsequently carried out based on a combination of subject words and free words.At the same time,references and the WHO clinical trial registration platform were retrieved to supplement relevant literature and improve recall rate.The retrieval time limit was from the building of each database to November 2019.3.Literature Quality Assessment:The literature screening and data extraction were carried out by two researchers according to the inclusion and exclusion criteria formulated in this study and under the guidance of the Cochrane Handbook for Systematic Reviews 5.1.0.Simultaneously,literature quality was evaluated and cross-checking was performed.Any discrepancy in the results will be determined and judged by a third researcher.Literature quality was evaluated from the following six aspects:Random sequence generation,Allocation concealment,Blinding method,Incomplete outcome data,Selective reporting,Other bias.4.Meta-analysis was performed using Rev Man 5.4 software.The data of binary variables were expressed by OR and 95%CI,and the data of numerical variables were expressed by MD and 95%CI.Heterogeneity between studies was determined by X~2test,and the degree of heterogeneity was judged by I~2.P>0.1 and I~2<50%indicate small heterogeneity among the included studies.In this regard,the fixed effect model should be utilized to calculate the pooled statistics.P≤0.1 and I~2≥50%indicate large heterogeneity among the included studies.In this regard,the reasons for the heterogeneity should be analyzed,and the random effect model should be utilized to calculate the pooled statistics after excluding the clinical heterogeneity.(The test level of the Meta-analysis was set toα=0.05).Results 1.A total of 130 relevant literatures were initially retrieved.Duplicate literature was eliminated,and unrelated literature was excluded after reading the titles and abstracts.After reading the full text,a total of 12 literatures were included in the study,all of which were randomized controlled trials,of which 9 were in Chinese and 3 in English,with a total of2130 subjects.2.It was shown in the results of Meta-analysis that in terms of the effectiveness of the treatment of ovarian cancer,the differences in VEGF,MMP-2,progression-free survival and overall response rate in the docetaxel combined with carboplatin group were statistically significant(P<0.05).In terms of safety,the docetaxel combined with carboplatin group showed no statistically significant difference in the incidence of neutropenia,nausea,thrombocytopenia,and alopecia(P>0.05).It is not yet believed that the docetaxel combined with carboplatin group has any difference in these adverse effects compared with other chemotherapy regimens.However,in terms of neurotoxicity,the incidence of neurotoxicity was lower in the docetaxel combined with carboplatin group,with a statistically significant difference(OR=0.31,95%CI[0.15,0.67],P<0.05).Conclusion Docetaxel combined with carboplatin chemotherapy has a positive effect of ovarian cancer,with high effective rate and good safety.Therefore,docetaxel combined with carboplatin can be extensively applied in clinical practice.Nevertheless,due to the small number of literature included in this study and the low study quality,more literature needs to be included in the study and randomized controlled trials of higher study quality need to be compared to analyze and refine the conclusion.