Study On The Characteristics Of Sleep Structure In Patients With Parkinson’s Disease And RBD And Their Correlation With Serum GDNF Levels

Objective This study combined with polysomnography(PSG)to compare the sleep structure of Parkinson’s disease(PD)patients with or without rapid eye movement sleep behavior disorder(RBD),and explore the correlation between the sleep structure of PD patients with RBD and the level of serum glial-derived neurotrophic factor(GDNF).Provide a new research approach for early prediction,clinical treatment,and improvement of the quality of life of Parkinson’s disease patients.Methods Fifty patients with Parkinson’s disease diagnosed at the First Affiliated Hospital of Jiamusi University and within Jiamusi City were selected from December 2019 to December2020,and general data(age,gender,age of onset,disease duration,medication use,etc.),motor and non-motor symptom assessment(including anxiety,depression,and cognitive scales),allnight polysomnography were collected from Parkinson’s patients who met the criteria.The subjects were divided into 22 cases of PD with RBD group and 28 cases of PD without RBD group according to the PSG results,and the differences and characteristics of sleep structure between the two groups were compared;serum GDNF levels in the two groups were measured by taking venous blood in the morning,and the correlation between sleep structure and serum GDNF in patients with PD with RBD was analyzed.Results1.Compared with the group with PD without RBD,the PD with RBD group had a longer duration of illness,required significantly higher doses of medication,had severe motor symptoms and poorer cognitive performance,and the differences were statistically significant(P<0.05);2.Compared between the two groups,the PD with RBD group had a significantly shorter total sleep time and decreased sleep efficiency,while the sleep latency was significantly longer,and the N1 percentage and The difference was statistically significant(P<0.05);3.The serum GDNF level in the PD with RBD group was significantly lower than that in the group without RBD,and the difference was statistically significant(P<0.05);4.The serum GDNF levels in the PD with onset RBD group were negatively correlated with the percentage of N1 stage in their sleep structure,which was statistically significant(r=-0.448 P<0.05)and with the percentage of REM stage,which was statistically significant(r=-0.504 P<0.05),and no significant correlation was seen with the remaining parameters of each sleep structure,which was not statistically significant(P>0.05);5.no significant correlation between the serum GDNF level and the parameters of the sleep structure in the group with PD without RBD,which was not statistically significant(P>0.05).Conclusions1.The sleep structure of patients with PD with RBD is characterized by sleep structure disorders with increased percentage of N1 stage and percentage of REM stage;2.The serum GDNF level of patients with PD with RBD is negatively correlated with the percentage of N1 stage and percentage of REM stage in their sleep structure,which may be involved in the occurrence and development of sleep structure disorders in PD with RBD.