The Differences And Related Factors Of PSG Sleep Structure In Patients With Parkinson’s Disease And Multiple System Atrophy

Objective:1.To study the difference of PSG sleep structure between PD and MSA patients;2.To explore the characteristics of anxiety,depression,and emotional cognitive strategies in PD and MSA patients and their correlation with PSG sleep structure;3.To explore the sleep-related serum marker levels of PD and MSA patients and their correlation with PSG sleep structure;4.The sleep,mood,and cognitive characteristics of PS patients with different TCM syndromes.method:Collecting PS patients and healthy controls: PSG,scales,and serological markers are complete and consistent with the diagnosis: there are 19 cases in the PD group,12 cases in the MSA group,and 15 cases in the healthy control group.The PS patients with complete scale data were included into the liver-qi invasion syndrome group(18cases)and the liver-qi depression syndrome group(14 cases)according to the dialectical classification of the theory of liver governing dredging and releasing.Collect the following information of subjects in detail:(1)Basic information: gender,age,course of illness,etc.;(2)All subjects undergo polysomnography(PSG)testing;(3)Issue questionnaires: Pittsburgh Sleep Quality Index(PSQI),Baker Anxiety Inventory(BAI),Baker Depression Inventory Second Edition(BDIⅡ),Dysfunctional Attitudes Scale(DAS-A),GROSS Emotion Regulation Questionnaire(ERQ),Cognitive Emotion Regulation Questionnaire(CERQ-C);(4)Detection of serum marker levels: serum brain-derived neurotrophic factor(BDNF),serum S100 B protein(S100B),serum neuron-specific enolase(NSE).Result:(1)The PD group and the MSA group have sleep disorders,and there are differences(p<0.05);the PD group’s N3,N3% of the sleep period is significantly lower than the MSA group and the healthy control group(p<0.05);the PD group The SE was significantly lower than the MSA group(p<0.05);for a large number of abnormal mandibular myoelectricity in the REM phase,the PD group(7 cases)accounted for higher than the MSA group and the healthy control group.(2)The PSQI of the PD group and MSA group was significantly higher than that of the healthy control group(p<0.05).The total scores of the PD group and MSA group on BAI and BDI Ⅱ were significantly higher than those of the healthy control group(p<0.01).The scores of PD group and MSA group on expression inhibition were significantly higher than that of the healthy control group,p<0.05.The scores of the PD group and the MSA group on vulnerability,attraction and repulsion,perfection,coercion,and autonomy were significantly higher than those of the healthy control group(p<0.05).When encountering negative events,the scores of acceptance and catastrophe in the PD group and MSA group were significantly higher than those in the healthy control group;the MSA group had a more obvious attitude towards catastrophe.(3)The NSE level of the PD group and MSA group was significantly higher than that of the healthy control group(p<0.05);the BDNF level of the PD group and MSA group was significantly lower than that of the healthy control group(p<0.05);(4)Depression(B=46.085,p=0.000),anxiety(B=38.867,p=0.000)emotions can negatively affect BDNF levels;depression(B=51.939,p=0.000),anxiety(B=52.844,p =0.000)emotions,CERQ factors(self-comfort(B=16.886,p=0.000),silent thoughts(B=20.144,p=0.000)),S100 B level(B=0.296,p=0.000)can negatively affect the sleep period Time;NSE level negatively affects total sleep time(B=8.825,p=0.000)and sleep efficiency(B=9.001,p=0.034);CERQ-C factor(self-comfort(B=7.921,p=0.009),blame Others(B=6.810,p=0.028)can positively affect the time to sleep;CERQ-C factors(self-comfort(B=7.844,p=0.008),blame others(B=6.828,p=0.000))can be positive N1 sleep latency;DAS-A factor(perfect(B=14.776,p=0.000))can positively affect REM sleep latency;ERQ factor(expression inhibition(B=13.732,p=0.045))can positively affect N3 time.(5)There is no difference in sleep between the liver-qi stagnation group and the liver-qi inversion group,but there are differences in mood and cognition(p<0.05).in conclusion:Both PD and MSA patients have sleep disorders.PD patients have lower sleep efficiency and N3 time than MSA patients,and the incidence of RBD is higher than MSA patients;PD and MSA patients suffer from anxiety and depression,emotional cognitive strategies,and serological markers in sleep influences.The anxiety and depression of PD patients and MSA patients are higher than that of healthy people and can negatively affect the level of BDNF.The level of NSE is higher than that of healthy people,and the level of BDNF is lower than that of healthy people.The higher the S100 B level,the shorter the sleep period;the higher the NSE level,the lower the total sleep time and sleep efficiency.Both of them suppress their emotions and behaviors more in the face of life events.They have vulnerability,obsessive-compulsive disorder,autonomous attitude,attraction and repulsion,pursuit of perfection,and tend to be non-adaptive strategies.The catastrophic attitude of MSA patients is more obvious.The patient’s emotion and cognitive adjustment strategies are related to the TCM classification.