Clinical Observation Of Weiermai No.4 In Treating Arteriosclerosis Obliterans Of Lower Extremities (Cold-dampness Blocking Syndrome)

Objective:This study discusses the effect of traditional Chinese medicine decoction and prostacyclin derivatives in the treatment of lower extremity arteriosclerosis obliterans of cold dampness blocking collaterals,and provides new theoretical basis and clinical ideas for the treatment of this disease in traditional Chinese medicine.Methods:From September 2020 to March 2021,62 patients with lower extremity arteriosclerosis occlusion(cold and wet obstruction collaterals)were selected to be numbered and grouped.All patients were randomly divided into control group and treatment group,31 patients were randomly divided into three groups.All patients were treated with the same basic treatment,namely,blood pressure control treatment,lipid regulating therapy and antiplatelet aggregation therapy.On this basis,the treatment group was treated by NO.4 Weiermai oral treatment,and was taken twice in the morning and evening twice in the morning and half an hour after dinner for 14 days.The control group was treated with Berprost sodium on the basis of routine treatment,and treated three times a day,40μg each time,and 14 days.After one course,the patients’ intermittent limp distance,ankle brachial index,foot back skin temperature and TCM syndrome score were evaluated.SPSS25.0was used to analyze the statistics.Results:(1)After the two methods,the difference between the two groups was significant(P < 0.05),and the difference between the treatment group and the control group was significant(P < 0.05).(2)After treatment,ABI index of the two groups was higher than that before treatment,and the difference was statistically significant(P < 0.05),and ABI index in treatment group was better than that of control group(P <0.05).(3)The temperature of the back of foot in the two groups was higher than that before treatment,the difference was statistically significant(P < 0.05),and the temperature of the treatment group was better than that of the control group(P < 0.05).(4)After two methods,the TCM syndrome score of the treatment group was improved by 90.32%,and the improvement rate of the control group was80.65%.The results showed that the therapeutic effect of the treatment group was better than that of the control group.Conclusion:(1)NO.4 Weiermai can improve the intermittent limp distance,brachial ankle index and foot back temperature in patients with cold and wet obstruction of lower extremity arteriosclerosis occlusion,and the therapeutic effect of the treatment group is better than that of the control group.(2)NO.4 Weiermai is superior to Beraprost sodiumin in improving the clinical symptoms and signs of patients with cold and wet obstruction of lower extremity arteriosclerosis occlusion.