Clinical Efficacy Observation Of Yiyin Zhuanggu Pill In The Treatment Of Postmenopausal Osteoporosis Of Liver-kidney Yin Deficiency Type

Objective:By combining with clinical practice,evaluate the clinical efficacy of the self-formulated formula Yiyin Zhuanggu Pill on postmenopausal osteoporosis with liver-kidney yin deficiency type.Methods:Seventy-two patients with postmenopausal osteoporosis who met the criteria of liver-kidney yin deficiency type were randomly divided into two groups:36 patients in the treatment group and 36 patients in the control group.All patients in the group were given calcium carbonate D3 and osteotriol pills,alendronate tablets in the control group and Yiyin Zhuanggu Pill in the treatment group;the treatment course was 24 weeks.The changes of hip bone mineral density(BMD),quantitative TCM syndrome score,TCM single syndrome score,and visual analogue scale(VAS)of low back pain were recorded before and after the study in the two groups respectively,and the clinical efficacy was evaluated by statistical analysis.Results:1.Comparison of the hip BMD:After 24 weeks of continuous treatment,the hip BMD was significantly higher in both groups(P<0.01),and the efficacy of both groups was comparable(P>0.05).2.Analysis of the efficacy of TCM symptoms:After 24 weeks of continuous treatment,comparing the total efficacy of TCM symptoms of the two groups,67.65%in the control group and 87.50%in the treatment group,the efficacy of the treatment group was better than that of the control group(P<0.05).3.Comparison of TCM symptom scores:Comparing the total TCM symptom scores,there was significant improvement in both groups after treatment(P<0.01),and the treatment group was significantly better than the control group after 12 weeks and 24 weeks of treatment(P<0.01);comparing the individual symptom scores within the group,after 12 weeks of treatment,the treatment group was better than the control group in the symptoms of the five upset hot and dryness in the eyes(P<0.05),after 24 weeks of treatment,the symptoms of low back pain,weakness of the knees,five upset hot,cramps in the lower limbs,difficulty in walking,difficulty in holding weight,dryness in the eyes,insomnia and dreaminess improved significantly in the treatment group(P<0.01),and tinnitus symptoms also improved(P<0.05),the control group only saw an improvement in the symptoms of low back pain,weakness of the knees,lower limb cramps,difficulty in walking and difficulty in holding weight(P<0.01),while the symptoms of five upset hot,insomnia and dreaminess,dryness of the eyes and tinnitus did not improve significantly compared with those before treatment(P>0.05);comparing the individual symptom scores between groups after 24 weeks of treatment,the efficacy of the treatment group was significantly better than the control group in improving the symptoms of the five upset hot,dryness in the eyes and tinnitus(P<0.01),in terms of symptoms of insomnia and dreaminess,the treatment group was more effective than the control group(P<0.05),the two groups were equally effective in improving the symptoms of low back pain,weakness of the knees,cramps in the lower limbs,difficulty in walking and difficulty in holding weight(P>0.05).4.Comparison of VAS scores:After 24 weeks of continuous treatment,there was a significant reduction in VAS scores in both groups compared to pre-treatment(P<0.01),and the improvement in VAS scores was comparable between the two groups after 12 and 24 weeks of treatment(P>0.05).Conclusion:1.Yiyin Zhuanggu Pill can clearly improve the hip BMD in PMOP patients of liver-kidney yin deficiency type.2.Yiyin Zhuanggu Pill can significantly improve the TCM symptom scores in PMOP patients of liver-kidney yin deficiency type.3.Yiyin Zhuanggu Pill can effectively alleviate the symptoms of low back pain,weakness in the knees,five upset hot,cramps in the lower limbs,difficulty in walking,difficulty in weight holding,insomnia and dreaminess,dryness in the eyes and tinnitus in PMOP patients of liver-kidney yin deficiency type.4.Yiyin Zhuanggu Pill can significantly reduce the VAS score of low back pain in PMOP patients of liver-kidney yin deficiency type.