The Role Of PPI In The Treatment Of Diarrhea

ObjectiveTo clarify the role and clinical significance of PPI in the treatment of diarrhea,and further improve the treatment of diarrhea.Method105 patients with acute diarrhea were randomly divided into experimental group A(PPIs combined with conventional treatment)and control group B(conventional treatment),and 108 patients with chronic diarrhea were equally divided into experimental group C(PPIs combined with conventional treatment)and control group D(conventional treatment)The follow-up time was 1 week,2 weeks,4 weeks and 10 weeks after treatment.The curative effect,remission,cure rate,length of hospital stay,anxiety and Depression Scale score and incidence of adverse reactions were compared between the two groups.T test,Mann Whitney U test,chi square test and Fisher exact probability method were used to process the data.Result1.(1)the treatment of diarrhea with PPI was not related to gender,age,height,weight,BMI and other factors(P > 0.05),and there was no statistical significance;(2)the average cure time of acute diarrhea experiment group A was about 2 days less than that of control group B,and the average cure time of chronic diarrhea experiment group C was about 4days less than that of control group D,and the differences were statistically significant(P< 0.05),indicating that the cure time was shortened after adding PPI.2.(1)the treatment effect of acute diarrhea in the two groups before 3 days,5 days and 7 days: the clinical total effective rate of experimental group A was 89.09%,which was significantly higher than that of control group B 72%,the clinical cure rate of experimental group A was 60.00%,which was significantly higher than that of control group B 40.00%,and the clinical total effective rate of experimental group A was 98.18%,which was significantly higher than that of control group B 88%,The clinical cure rate of experimental group A was 98.18%,which was significantly higher than that of control group B(76%),the differences were statistically significant(P < 0.05).7 days before treatment,the clinical total effective rates of experimental group A and control group B were 100% and 98% respectively,and the clinical cure rates were 100% and 98%respectively,with no significant difference(P > 0.05).(2)comparison of clinical symptom scores before treatment,3 days and 7 days after treatment between the two groups: there was no significant difference in clinical symptom scores before treatment(P > 0.05),but 3days and 7 days after treatment between the two groups The clinical symptom score of group A was lower than that of group B(P < 0.05);3.(1)four days,one week and two weeks before treatment,the total effective rate of experimental group C was 92.30%,which was significantly higher than that of control group D(76.79%),and the clinical cure rate of experimental group C was 38.46%,which was significantly higher than that of control group D(28.57%).One week after treatment,the total effective rate of experimental group C was 96.15%,which was significantly higher than that of control group D(82.93%),and the clinical cure rate of experimental group C was 94.23% The difference was statistically significant(P < 0.05).In the first two weeks after treatment,the clinical total effective rates of experimental group C and control group D were 100% and 94.64% respectively,and there was no statistical significance between the two groups(P > 0.05),but the clinical cure rate of experimental group C was98.08%,which was significantly higher than that of control group D(85.71%),and the difference was statistically significant(P < 0.05).(2)comparison of clinical symptom scores of chronic diarrhea before treatment,1 week,2 weeks,4 weeks and 10 weeks after treatment between the two groups: There was no statistical significance in the clinical symptom score of the two groups before treatment(P > 0.05).The clinical symptom score of the experimental group C was lower than that of the control group D on the 4th day,1st week,2nd week,4th week and 8th week after treatment,but the symptom score of the 4th week after treatment was higher than that of the 2nd week,and the symptom score of the8 th week was significantly higher than that of the 4th week,with statistical significance(P< 0.05).4.Comparison of chronic diarrhea anxiety and Depression Scale score: there was no significant difference in anxiety and depression score between the two groups before treatment(P > 0.05),but the score of control group D was higher than that of experimental group C after treatment(P < 0.05).5.Comparison of adverse reactions: there was no significant difference in the incidence and total incidence of adverse reactions such as nausea,vomiting,rash and constipation among the four groups(P > 0.05);Conclusion1.PPI is effective in the treatment of acute and chronic diarrhea,and can be used in the clinical treatment of diarrhea.2.PPI can relieve the symptoms and signs of diarrhea,shorten the course of disease and improve the cure rate.3.PPI has a good short-term effect on chronic diarrhea,and there is no difference between the long-term effect and conventional treatment.